Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments

Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome compos...

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Main Authors: Elizaveta Vinogradova, Zharkyn Jarmukhanov, Madiyar Nurgaziyev, Alibek Kossumov, Ayaulym Nurgozhina, Nurislam Mukhanbetzhanov, Shynggys Sergazy, Laura Chulenabyeva, Argul Issilbayeva, Sholpan Askarova, Aiym Kaiyrlykyzy, Saule Rakhimova, Ulan Kozhamkulov, Ulykbek Kairov, Zhanagul Khassenbekova, Dinar Tarzhanova, Ainur Akilzhanova, Joseph H. Lee, Joseph Terwilliger, Aliya Sailybayeva, Makhabbat Bekbossynova, Zhaxybay Zhumadilov, Samat Kozhakhmetov, Almagul Kushugulova
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003494
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author Elizaveta Vinogradova
Zharkyn Jarmukhanov
Madiyar Nurgaziyev
Alibek Kossumov
Ayaulym Nurgozhina
Nurislam Mukhanbetzhanov
Shynggys Sergazy
Laura Chulenabyeva
Argul Issilbayeva
Sholpan Askarova
Aiym Kaiyrlykyzy
Saule Rakhimova
Ulan Kozhamkulov
Ulykbek Kairov
Zhanagul Khassenbekova
Dinar Tarzhanova
Ainur Akilzhanova
Joseph H. Lee
Joseph Terwilliger
Aliya Sailybayeva
Makhabbat Bekbossynova
Zhaxybay Zhumadilov
Samat Kozhakhmetov
Almagul Kushugulova
author_facet Elizaveta Vinogradova
Zharkyn Jarmukhanov
Madiyar Nurgaziyev
Alibek Kossumov
Ayaulym Nurgozhina
Nurislam Mukhanbetzhanov
Shynggys Sergazy
Laura Chulenabyeva
Argul Issilbayeva
Sholpan Askarova
Aiym Kaiyrlykyzy
Saule Rakhimova
Ulan Kozhamkulov
Ulykbek Kairov
Zhanagul Khassenbekova
Dinar Tarzhanova
Ainur Akilzhanova
Joseph H. Lee
Joseph Terwilliger
Aliya Sailybayeva
Makhabbat Bekbossynova
Zhaxybay Zhumadilov
Samat Kozhakhmetov
Almagul Kushugulova
author_sort Elizaveta Vinogradova
collection DOAJ
description Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.
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spelling doaj-art-1bf11fd8e0db463ba67781541a1ac5032025-02-02T05:28:40ZengElsevierHeliyon2405-84402025-01-01112e41969Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairmentsElizaveta Vinogradova0Zharkyn Jarmukhanov1Madiyar Nurgaziyev2Alibek Kossumov3Ayaulym Nurgozhina4Nurislam Mukhanbetzhanov5Shynggys Sergazy6Laura Chulenabyeva7Argul Issilbayeva8Sholpan Askarova9Aiym Kaiyrlykyzy10Saule Rakhimova11Ulan Kozhamkulov12Ulykbek Kairov13Zhanagul Khassenbekova14Dinar Tarzhanova15Ainur Akilzhanova16Joseph H. Lee17Joseph Terwilliger18Aliya Sailybayeva19Makhabbat Bekbossynova20Zhaxybay Zhumadilov21Samat Kozhakhmetov22Almagul Kushugulova23Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanDepartment of General Pharmacology, Astana Medical University, Astana, KazakhstanDepartment of General Pharmacology, Astana Medical University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, KazakhstanSergievsky Center, Taub Institute, Department of Neurology and Epidemiology, Columbia University, New York, NY, USADepartment of Psychiatry and Genetics & Development, Sergievsky Center, Columbia University, New York, NY, USA; Division of Public Health Genomics, National Institute for Ealth and Welfare, Helsinki, FinlandNational Research Cardiac Surgery Center, Astana, KazakhstanNational Research Cardiac Surgery Center, Astana, KazakhstanSchool of Medicine, Nazarbayev University, Astana, KazakhstanCenter for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan; Corresponding author.Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan; National Research Cardiac Surgery Center, Astana, Kazakhstan; Corresponding author. Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.http://www.sciencedirect.com/science/article/pii/S2405844025003494Memory performanceMetagenomicsButyrate producersEnterococcus dysbiosisVitamin D deficiencyGut microbiome
spellingShingle Elizaveta Vinogradova
Zharkyn Jarmukhanov
Madiyar Nurgaziyev
Alibek Kossumov
Ayaulym Nurgozhina
Nurislam Mukhanbetzhanov
Shynggys Sergazy
Laura Chulenabyeva
Argul Issilbayeva
Sholpan Askarova
Aiym Kaiyrlykyzy
Saule Rakhimova
Ulan Kozhamkulov
Ulykbek Kairov
Zhanagul Khassenbekova
Dinar Tarzhanova
Ainur Akilzhanova
Joseph H. Lee
Joseph Terwilliger
Aliya Sailybayeva
Makhabbat Bekbossynova
Zhaxybay Zhumadilov
Samat Kozhakhmetov
Almagul Kushugulova
Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
Heliyon
Memory performance
Metagenomics
Butyrate producers
Enterococcus dysbiosis
Vitamin D deficiency
Gut microbiome
title Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
title_full Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
title_fullStr Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
title_full_unstemmed Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
title_short Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments
title_sort enterococcus dysbiosis as a mediator of vitamin d deficiency associated memory impairments
topic Memory performance
Metagenomics
Butyrate producers
Enterococcus dysbiosis
Vitamin D deficiency
Gut microbiome
url http://www.sciencedirect.com/science/article/pii/S2405844025003494
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