Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database
ObjectiveTo investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given the emerging importance of biological aging as a health determinant and the role of insulin resistance in aging-related processes.MethodsThis cross-sectional study...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1548690/full |
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| author | Zhili Zhao Zhili Zhao Yan Liang Yan Liang |
| author_facet | Zhili Zhao Zhili Zhao Yan Liang Yan Liang |
| author_sort | Zhili Zhao |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given the emerging importance of biological aging as a health determinant and the role of insulin resistance in aging-related processes.MethodsThis cross-sectional study analyzed data from 13,291 adults aged ≥20 years in the National Health and Nutrition Examination Survey (1999–2010). The TyG index served as the exposure variable, calculated from fasting triglycerides and glucose levels. PhenoAgeAccel, derived from clinical biomarkers, was the outcome variable. Analyses adjusted for demographic, socioeconomic, and health-related covariates.ResultsA significant non-linear relationship was observed between TyG index and PhenoAgeAccel, with an inflection point at 9.60. In the fully adjusted model, each unit increase in TyG index was associated with 2.21 years increase in PhenoAgeAccel (95% CI: 1.99, 2.43). The association was stronger above the inflection point (β = 8.21, 95% CI: 7.59, 8.82) compared to below it (β = 0.56, 95% CI: 0.29, 0.83).ConclusionHigher TyG index levels are significantly associated with accelerated biological aging, particularly above a threshold of 9.60. These findings suggest the importance of metabolic health in biological aging processes and potential interventional strategies. |
| format | Article |
| id | doaj-art-1bee939416af405c87b4ff9a2aac9c6a |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-1bee939416af405c87b4ff9a2aac9c6a2025-08-20T03:51:58ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-05-011610.3389/fphys.2025.15486901548690Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES databaseZhili Zhao0Zhili Zhao1Yan Liang2Yan Liang3Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Nursing, Sichuan University, Chengdu, ChinaWest China School of Nursing, Sichuan University, Chengdu, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaObjectiveTo investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given the emerging importance of biological aging as a health determinant and the role of insulin resistance in aging-related processes.MethodsThis cross-sectional study analyzed data from 13,291 adults aged ≥20 years in the National Health and Nutrition Examination Survey (1999–2010). The TyG index served as the exposure variable, calculated from fasting triglycerides and glucose levels. PhenoAgeAccel, derived from clinical biomarkers, was the outcome variable. Analyses adjusted for demographic, socioeconomic, and health-related covariates.ResultsA significant non-linear relationship was observed between TyG index and PhenoAgeAccel, with an inflection point at 9.60. In the fully adjusted model, each unit increase in TyG index was associated with 2.21 years increase in PhenoAgeAccel (95% CI: 1.99, 2.43). The association was stronger above the inflection point (β = 8.21, 95% CI: 7.59, 8.82) compared to below it (β = 0.56, 95% CI: 0.29, 0.83).ConclusionHigher TyG index levels are significantly associated with accelerated biological aging, particularly above a threshold of 9.60. These findings suggest the importance of metabolic health in biological aging processes and potential interventional strategies.https://www.frontiersin.org/articles/10.3389/fphys.2025.1548690/fullTyG indexphenotypic age accelerationinsulin resistancemetabolic dysfunctioncross-sectional studynational health and nutrition examination survey (NHANES) |
| spellingShingle | Zhili Zhao Zhili Zhao Yan Liang Yan Liang Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database Frontiers in Physiology TyG index phenotypic age acceleration insulin resistance metabolic dysfunction cross-sectional study national health and nutrition examination survey (NHANES) |
| title | Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database |
| title_full | Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database |
| title_fullStr | Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database |
| title_full_unstemmed | Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database |
| title_short | Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database |
| title_sort | association between triglyceride glucose index and phenotypic age acceleration a cross sectional study based on nhanes database |
| topic | TyG index phenotypic age acceleration insulin resistance metabolic dysfunction cross-sectional study national health and nutrition examination survey (NHANES) |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1548690/full |
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