DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone
Transition metal complexes of copper(II), nickel(II), cobalt(II) and iron(II) with benzil-α-monoxime thiosemicarbazone (BMOT) have been synthesized and characterized by molar conductance, magnetic moments, IR, electronic and ESR spectroscopy. Electrochemical behaviors of these complexes were investi...
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| Format: | Article |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/567979 |
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| author | M. S. Surendra Babu T. B. Patrudu K. Hussain Reddy |
| author_facet | M. S. Surendra Babu T. B. Patrudu K. Hussain Reddy |
| author_sort | M. S. Surendra Babu |
| collection | DOAJ |
| description | Transition metal complexes of copper(II), nickel(II), cobalt(II) and iron(II) with benzil-α-monoxime thiosemicarbazone (BMOT) have been synthesized and characterized by molar conductance, magnetic moments, IR, electronic and ESR spectroscopy. Electrochemical behaviors of these complexes were investigated by cyclic voltammetric studies. The nuclease activity of these complexes has been investigated on double-stranded pBR322 circular plasmid DNA by using the gel electrophoresis experiments in presence and absence of oxidant (H2O2). In the absence of oxidant DNA cleavage by hydrolytically was observed a less discernable, whereas in presence of oxidant (H2O2) all complexes showed increased nuclease activity. |
| format | Article |
| id | doaj-art-1bed39eaef0e436f8fa283d2e7ef2032 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-1bed39eaef0e436f8fa283d2e7ef20322025-02-03T06:00:44ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018S1S309S31710.1155/2011/567979DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime ThiosemicarbzoneM. S. Surendra Babu0T. B. Patrudu1K. Hussain Reddy2Department of Chemistry, Gitam University, Hyderabad-502 329, IndiaDepartment of Chemistry, Gitam University, Hyderabad-502 329, IndiaDepartment of Chemistry, Sri Krishnadevaraya University, Anantapur-515 002, IndiaTransition metal complexes of copper(II), nickel(II), cobalt(II) and iron(II) with benzil-α-monoxime thiosemicarbazone (BMOT) have been synthesized and characterized by molar conductance, magnetic moments, IR, electronic and ESR spectroscopy. Electrochemical behaviors of these complexes were investigated by cyclic voltammetric studies. The nuclease activity of these complexes has been investigated on double-stranded pBR322 circular plasmid DNA by using the gel electrophoresis experiments in presence and absence of oxidant (H2O2). In the absence of oxidant DNA cleavage by hydrolytically was observed a less discernable, whereas in presence of oxidant (H2O2) all complexes showed increased nuclease activity.http://dx.doi.org/10.1155/2011/567979 |
| spellingShingle | M. S. Surendra Babu T. B. Patrudu K. Hussain Reddy DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone E-Journal of Chemistry |
| title | DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone |
| title_full | DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone |
| title_fullStr | DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone |
| title_full_unstemmed | DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone |
| title_short | DNA Binding and Cleavage Activity of Binuclear Metal Complexes with Benzil-α-Monoxime Thiosemicarbzone |
| title_sort | dna binding and cleavage activity of binuclear metal complexes with benzil α monoxime thiosemicarbzone |
| url | http://dx.doi.org/10.1155/2011/567979 |
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