Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine
Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist currently used in clinical settings. Because DEX has dose-dependent advantages of sedation, analgesia, antianxiety, inhibition of sympathetic nervous system activity, cardiovascular stabilization, and significant reduc...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/6136105 |
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| author | Naren Bao Bing Tang |
| author_facet | Naren Bao Bing Tang |
| author_sort | Naren Bao |
| collection | DOAJ |
| description | Dexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist currently used in clinical settings. Because DEX has dose-dependent advantages of sedation, analgesia, antianxiety, inhibition of sympathetic nervous system activity, cardiovascular stabilization, and significant reduction of postoperative delirium and agitation, but does not produce respiratory depression and agitation, it is widely used in clinical anesthesia and ICU departments. In recent years, much clinical study and basic research has confirmed that DEX has a protective effect on a variety of organs, including the nervous system, heart, lungs, kidneys, liver, and small intestine. It acts by reducing the inflammatory response in these organs, activating antiapoptotic signaling pathways which protect cells from damage. Therefore, based on wide clinical application and safety, DEX may become a promising clinical multiorgan protection drug in the future. In this article, we review the physiological effects related to organ protection in α2AR agonists along with the organ-protective effects and mechanisms of DEX to understand their combined application value. |
| format | Article |
| id | doaj-art-1be508ae03af4cba8512d52e98eefcee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1be508ae03af4cba8512d52e98eefcee2025-08-20T03:54:51ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/61361056136105Organ-Protective Effects and the Underlying Mechanism of DexmedetomidineNaren Bao0Bing Tang1Department of Anesthesiology, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, ChinaDepartment of Anesthesiology, The First Hospital of China Medical University, 155 Nanjing North Street, Shenyang, ChinaDexmedetomidine (DEX) is a highly selective α2 adrenergic receptor (α2AR) agonist currently used in clinical settings. Because DEX has dose-dependent advantages of sedation, analgesia, antianxiety, inhibition of sympathetic nervous system activity, cardiovascular stabilization, and significant reduction of postoperative delirium and agitation, but does not produce respiratory depression and agitation, it is widely used in clinical anesthesia and ICU departments. In recent years, much clinical study and basic research has confirmed that DEX has a protective effect on a variety of organs, including the nervous system, heart, lungs, kidneys, liver, and small intestine. It acts by reducing the inflammatory response in these organs, activating antiapoptotic signaling pathways which protect cells from damage. Therefore, based on wide clinical application and safety, DEX may become a promising clinical multiorgan protection drug in the future. In this article, we review the physiological effects related to organ protection in α2AR agonists along with the organ-protective effects and mechanisms of DEX to understand their combined application value.http://dx.doi.org/10.1155/2020/6136105 |
| spellingShingle | Naren Bao Bing Tang Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine Mediators of Inflammation |
| title | Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine |
| title_full | Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine |
| title_fullStr | Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine |
| title_full_unstemmed | Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine |
| title_short | Organ-Protective Effects and the Underlying Mechanism of Dexmedetomidine |
| title_sort | organ protective effects and the underlying mechanism of dexmedetomidine |
| url | http://dx.doi.org/10.1155/2020/6136105 |
| work_keys_str_mv | AT narenbao organprotectiveeffectsandtheunderlyingmechanismofdexmedetomidine AT bingtang organprotectiveeffectsandtheunderlyingmechanismofdexmedetomidine |