Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice
ABSTRACT Purpose: To evaluate membranes originating from pure or oxidized bacterial cellulose (BC)/alginate/strontium apatite hydrogels regarding toxicity, biocompatibility, biodegradation and metabolism. Methods: The toxicity was measured by incubating the materials with Artemia salina for 24 h,...
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2025-03-01
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| Series: | Acta Cirúrgica Brasileira |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100208&tlng=en |
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| author | Juliana Dantas da Costa Erika Iara de Souza Araújo Juan Feliphe Silva de Castro Tamiris Bezerra Costa Érika Patrícia Chagas Gomes Luz Rodrigo Silveira Vieira Igor Iuco Castro-Silva |
| author_facet | Juliana Dantas da Costa Erika Iara de Souza Araújo Juan Feliphe Silva de Castro Tamiris Bezerra Costa Érika Patrícia Chagas Gomes Luz Rodrigo Silveira Vieira Igor Iuco Castro-Silva |
| author_sort | Juliana Dantas da Costa |
| collection | DOAJ |
| description | ABSTRACT Purpose: To evaluate membranes originating from pure or oxidized bacterial cellulose (BC)/alginate/strontium apatite hydrogels regarding toxicity, biocompatibility, biodegradation and metabolism. Methods: The toxicity was measured by incubating the materials with Artemia salina for 24 h, and mortality and the 50% lethal concentration were determined in comparison to potassium dichromate by Probit analysis. Local biocompatibility and biodegradation were evaluated by subcutaneous assay in 75 Swiss mice; the test groups were compared to sham and collagen membrane at one, three and nine weeks. The histopathology of tissue irritation followed the ISO 10993-6 standard, and the integrity of the biomaterials scored by quartiles. Metabolic analysis of relative weight and the intensity of catalase, iodine and nitrite were carried out for liver, kidneys and tibias of the tested animals. Results: All cellulose-based materials were nontoxic, biocompatible, and none presented nitrosative stress. The oxidized BC was more resorbable, and the non-oxidized BC had greater renal biochemical reactivity. Conclusion: The membranes suggest applicability as regenerative barriers. However, long-term studies in bone defects are necessary to elucidate their osteopromoting efficiency. |
| format | Article |
| id | doaj-art-1bdabc07efa5497bb3a27252b9cbecdb |
| institution | OA Journals |
| issn | 1678-2674 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj-art-1bdabc07efa5497bb3a27252b9cbecdb2025-08-20T01:54:45ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742025-03-014010.1590/acb401925Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in miceJuliana Dantas da Costahttps://orcid.org/0000-0002-3321-6436Erika Iara de Souza Araújohttps://orcid.org/0009-0009-5935-2776Juan Feliphe Silva de Castrohttps://orcid.org/0009-0009-0997-2918Tamiris Bezerra Costahttps://orcid.org/0009-0002-4189-2474Érika Patrícia Chagas Gomes Luzhttps://orcid.org/0000-0003-4873-8197Rodrigo Silveira Vieirahttps://orcid.org/0000-0003-4569-9655Igor Iuco Castro-Silvahttps://orcid.org/0000-0003-4815-6357ABSTRACT Purpose: To evaluate membranes originating from pure or oxidized bacterial cellulose (BC)/alginate/strontium apatite hydrogels regarding toxicity, biocompatibility, biodegradation and metabolism. Methods: The toxicity was measured by incubating the materials with Artemia salina for 24 h, and mortality and the 50% lethal concentration were determined in comparison to potassium dichromate by Probit analysis. Local biocompatibility and biodegradation were evaluated by subcutaneous assay in 75 Swiss mice; the test groups were compared to sham and collagen membrane at one, three and nine weeks. The histopathology of tissue irritation followed the ISO 10993-6 standard, and the integrity of the biomaterials scored by quartiles. Metabolic analysis of relative weight and the intensity of catalase, iodine and nitrite were carried out for liver, kidneys and tibias of the tested animals. Results: All cellulose-based materials were nontoxic, biocompatible, and none presented nitrosative stress. The oxidized BC was more resorbable, and the non-oxidized BC had greater renal biochemical reactivity. Conclusion: The membranes suggest applicability as regenerative barriers. However, long-term studies in bone defects are necessary to elucidate their osteopromoting efficiency.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100208&tlng=enCelluloseStrontiumHydroxyapatitesMaterials TestingBiocompatible MaterialsGuided Tissue Regeneration |
| spellingShingle | Juliana Dantas da Costa Erika Iara de Souza Araújo Juan Feliphe Silva de Castro Tamiris Bezerra Costa Érika Patrícia Chagas Gomes Luz Rodrigo Silveira Vieira Igor Iuco Castro-Silva Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice Acta Cirúrgica Brasileira Cellulose Strontium Hydroxyapatites Materials Testing Biocompatible Materials Guided Tissue Regeneration |
| title | Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice |
| title_full | Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice |
| title_fullStr | Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice |
| title_full_unstemmed | Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice |
| title_short | Evaluation of toxicity, local biocompatibility, biodegradation, and systemic metabolism of cellulose/alginate/strontium apatite membranes implanted subcutaneously in mice |
| title_sort | evaluation of toxicity local biocompatibility biodegradation and systemic metabolism of cellulose alginate strontium apatite membranes implanted subcutaneously in mice |
| topic | Cellulose Strontium Hydroxyapatites Materials Testing Biocompatible Materials Guided Tissue Regeneration |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502025000100208&tlng=en |
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