Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/7232793 |
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| author | Hongbo Li Shutao Lei Yongqiong Tang Liyuan Zou Hongqin Hu Suqin Wang |
| author_facet | Hongbo Li Shutao Lei Yongqiong Tang Liyuan Zou Hongqin Hu Suqin Wang |
| author_sort | Hongbo Li |
| collection | DOAJ |
| description | To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding. |
| format | Article |
| id | doaj-art-1bd3be9c17894e3cb762845eb5287b86 |
| institution | DOAJ |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-1bd3be9c17894e3cb762845eb5287b862025-08-20T03:17:52ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/72327937232793Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNAHongbo Li0Shutao Lei1Yongqiong Tang2Liyuan Zou3Hongqin Hu4Suqin Wang5Key Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaKey Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaTo assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.http://dx.doi.org/10.1155/2018/7232793 |
| spellingShingle | Hongbo Li Shutao Lei Yongqiong Tang Liyuan Zou Hongqin Hu Suqin Wang Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA Journal of Chemistry |
| title | Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA |
| title_full | Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA |
| title_fullStr | Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA |
| title_full_unstemmed | Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA |
| title_short | Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA |
| title_sort | drug effect of thulium iii arsenazo iii complex on herring sperm dna |
| url | http://dx.doi.org/10.1155/2018/7232793 |
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