Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword
Gliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic resistance among multiple cancers and gliomas. Since...
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Mashhad University of Medical Sciences
2025-01-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_25003_30e0ec7bebb9991d7d60d418fd7b74b0.pdf |
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| author | Negin Masoomabadi Ali Gorji Tahereh Ghadiri Safieh Ebrahimi |
| author_facet | Negin Masoomabadi Ali Gorji Tahereh Ghadiri Safieh Ebrahimi |
| author_sort | Negin Masoomabadi |
| collection | DOAJ |
| description | Gliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic resistance among multiple cancers and gliomas. Since circRNAs are aberrantly expressed in glioma and may act as promoters or inhibitors of therapeutic resistance, we categorized alterations of these specific RNAs expression in therapy resistant-glioma in three different classes, including chemoresistance, radioresistance, and glioma stem cell (GSC)-regulation. circRNAs act as competing endogenous RNA, sponging target microRNA and consequently affecting the expression of genes related to glioma tumorigenesis and resistance. By doing so, circRNAs can modulate the critical cellular pathways and processes regulating glioma resistance, including DNA repair pathways, GSC, epithelial-mesenchymal transition, apoptosis, and autophagy. Considering the poor survival and increased resistance to currently approved treatments for glioma, it is crucial to increase the knowledge of the resistance regulatory effects of circRNAs and their underlying molecular mechanisms. Herein, we conducted a comprehensive search and discussed the existing knowledge regarding the important role eof circRNAs in the emergence of resistance to therapeutic interventions in glioma. This knowledge may serve as a basis for enhancing the effectiveness of glioma therapeutic strategies. |
| format | Article |
| id | doaj-art-1bcde79ce6614d7783b3afeacce8e27e |
| institution | DOAJ |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-1bcde79ce6614d7783b3afeacce8e27e2025-08-20T02:48:06ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742025-01-0128131510.22038/ijbms.2024.81644.1766925003Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged swordNegin Masoomabadi0Ali Gorji1Tahereh Ghadiri2Safieh Ebrahimi3Department of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranShefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, IranDepartment of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranShefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, IranGliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic resistance among multiple cancers and gliomas. Since circRNAs are aberrantly expressed in glioma and may act as promoters or inhibitors of therapeutic resistance, we categorized alterations of these specific RNAs expression in therapy resistant-glioma in three different classes, including chemoresistance, radioresistance, and glioma stem cell (GSC)-regulation. circRNAs act as competing endogenous RNA, sponging target microRNA and consequently affecting the expression of genes related to glioma tumorigenesis and resistance. By doing so, circRNAs can modulate the critical cellular pathways and processes regulating glioma resistance, including DNA repair pathways, GSC, epithelial-mesenchymal transition, apoptosis, and autophagy. Considering the poor survival and increased resistance to currently approved treatments for glioma, it is crucial to increase the knowledge of the resistance regulatory effects of circRNAs and their underlying molecular mechanisms. Herein, we conducted a comprehensive search and discussed the existing knowledge regarding the important role eof circRNAs in the emergence of resistance to therapeutic interventions in glioma. This knowledge may serve as a basis for enhancing the effectiveness of glioma therapeutic strategies.https://ijbms.mums.ac.ir/article_25003_30e0ec7bebb9991d7d60d418fd7b74b0.pdfcancer therapychemoresistancecircrnasdrug resistanceglioblastomagliomanoncoding rnaradioresistance |
| spellingShingle | Negin Masoomabadi Ali Gorji Tahereh Ghadiri Safieh Ebrahimi Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword Iranian Journal of Basic Medical Sciences cancer therapy chemoresistance circrnas drug resistance glioblastoma glioma noncoding rna radioresistance |
| title | Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword |
| title_full | Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword |
| title_fullStr | Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword |
| title_full_unstemmed | Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword |
| title_short | Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword |
| title_sort | regulatory role of circular rnas in the development of therapeutic resistance in the glioma a double edged sword |
| topic | cancer therapy chemoresistance circrnas drug resistance glioblastoma glioma noncoding rna radioresistance |
| url | https://ijbms.mums.ac.ir/article_25003_30e0ec7bebb9991d7d60d418fd7b74b0.pdf |
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