Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion
IntroductionDogs homozygous for the SOD1 gene mutation with presumptive degenerative myelopathy (DM) can develop concurrent intervertebral disc protrusion (IVDP). The impact of IVDP on the progression of SOD1-related clinical signs is unknown. The aim of this study was to describe a population of do...
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Frontiers Media S.A.
2025-05-01
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| author | Péter Sebestyén Malwina Ewa Kowalska Malwina Ewa Kowalska Lorenzo Golini |
| author_facet | Péter Sebestyén Malwina Ewa Kowalska Malwina Ewa Kowalska Lorenzo Golini |
| author_sort | Péter Sebestyén |
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| description | IntroductionDogs homozygous for the SOD1 gene mutation with presumptive degenerative myelopathy (DM) can develop concurrent intervertebral disc protrusion (IVDP). The impact of IVDP on the progression of SOD1-related clinical signs is unknown. The aim of this study was to describe a population of dogs with the SOD1 mutation and to compare survival and time to non-ambulation between those with and without IVDP.MethodsThis single-center exploratory cohort study was preregistered and retrospectively included dogs with the SOD1 gene mutation, compatible clinical signs, and available spinal magnetic resonance imaging (MRI). Dogs were divided into two groups based on the presence (IVDP+) or absence (IVDP-) of IVDP affecting the T3-L3 spinal cord segment. The primary outcomes were time to euthanasia from the onset of clinical signs (neurological deficits) and from the diagnosis (genetic testing and MRI). The secondary outcome was time to non-ambulatory status. Data were analyzed using descriptive statistics and survival analysis.ResultsA total of 39 dogs were enrolled in the study, with a mean age of 115 months and a mean weight of 29 kg at the time of diagnosis. The most common breed was the German Shepherd (n = 9/39). In the IVDP- group (n = 28/39), the median survival time was 13 months (95% CI: 9–18 months) from the onset of clinical signs, and 6 months (95% CI: 5–11 months) from the time of diagnosis. In the IVDP+ group (n = 11/39), the median survival time was 11 months (95% CI: 9-∞ months) from the onset of clinical signs, and 7 months (95% CI: 5-∞ months) from the diagnosis. Cox regression analysis indicated that dogs with IVDP had a hazard ratio of 1.20 for euthanasia (95% CI: 0.58–2.49, p = 0.6), which was not statistically significant compared to dogs without IVDP.DiscussionBased on this retrospective cohort, dogs with the SOD1 mutation appear to have similar disease progression and survival, regardless of the presence of concurrent IVDP.Clinical trial registrationThe study has been preregistered on https://preclinicaltrials.eu/ (PCT ID: PCTE0000406). |
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| institution | Kabale University |
| issn | 2297-1769 |
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| publishDate | 2025-05-01 |
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| spelling | doaj-art-1bcb48fb1c7c4028b80a914b8c334c5f2025-08-20T03:53:07ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-05-011210.3389/fvets.2025.15558891555889Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusionPéter Sebestyén0Malwina Ewa Kowalska1Malwina Ewa Kowalska2Lorenzo Golini3Department of Small Animals, Section of Neurology, Vetsuisse Faculty Zurich, University of Zurich, Zurich, SwitzerlandEquine Department, Section of Ophthalmology, Vetsuisse Faculty Zurich, University of Zurich, Zurich, SwitzerlandSection of Epidemiology, Vetsuisse Faculty Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Small Animals, Section of Neurology, Vetsuisse Faculty Zurich, University of Zurich, Zurich, SwitzerlandIntroductionDogs homozygous for the SOD1 gene mutation with presumptive degenerative myelopathy (DM) can develop concurrent intervertebral disc protrusion (IVDP). The impact of IVDP on the progression of SOD1-related clinical signs is unknown. The aim of this study was to describe a population of dogs with the SOD1 mutation and to compare survival and time to non-ambulation between those with and without IVDP.MethodsThis single-center exploratory cohort study was preregistered and retrospectively included dogs with the SOD1 gene mutation, compatible clinical signs, and available spinal magnetic resonance imaging (MRI). Dogs were divided into two groups based on the presence (IVDP+) or absence (IVDP-) of IVDP affecting the T3-L3 spinal cord segment. The primary outcomes were time to euthanasia from the onset of clinical signs (neurological deficits) and from the diagnosis (genetic testing and MRI). The secondary outcome was time to non-ambulatory status. Data were analyzed using descriptive statistics and survival analysis.ResultsA total of 39 dogs were enrolled in the study, with a mean age of 115 months and a mean weight of 29 kg at the time of diagnosis. The most common breed was the German Shepherd (n = 9/39). In the IVDP- group (n = 28/39), the median survival time was 13 months (95% CI: 9–18 months) from the onset of clinical signs, and 6 months (95% CI: 5–11 months) from the time of diagnosis. In the IVDP+ group (n = 11/39), the median survival time was 11 months (95% CI: 9-∞ months) from the onset of clinical signs, and 7 months (95% CI: 5-∞ months) from the diagnosis. Cox regression analysis indicated that dogs with IVDP had a hazard ratio of 1.20 for euthanasia (95% CI: 0.58–2.49, p = 0.6), which was not statistically significant compared to dogs without IVDP.DiscussionBased on this retrospective cohort, dogs with the SOD1 mutation appear to have similar disease progression and survival, regardless of the presence of concurrent IVDP.Clinical trial registrationThe study has been preregistered on https://preclinicaltrials.eu/ (PCT ID: PCTE0000406).https://www.frontiersin.org/articles/10.3389/fvets.2025.1555889/fullcaninemagnetic resonance imagingspinal cord diseasedegenerative myelopathyKaplan–Meier survival analysis |
| spellingShingle | Péter Sebestyén Malwina Ewa Kowalska Malwina Ewa Kowalska Lorenzo Golini Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion Frontiers in Veterinary Science canine magnetic resonance imaging spinal cord disease degenerative myelopathy Kaplan–Meier survival analysis |
| title | Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| title_full | Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| title_fullStr | Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| title_full_unstemmed | Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| title_short | Survival and deterioration time of walking abilities in dogs homozygous for the SOD1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| title_sort | survival and deterioration time of walking abilities in dogs homozygous for the sod1 gene mutation with and without thoracolumbar intervertebral disc protrusion |
| topic | canine magnetic resonance imaging spinal cord disease degenerative myelopathy Kaplan–Meier survival analysis |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1555889/full |
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