Current Approach to The Treatment of Infantile Hemangioma
Infantile hemangioma (IH) is the most common benign vascular tumor of the infantile period. Although the etiopathology of IH is not well-known, two primary theories exist. The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-...
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Istanbul University Press
2023-03-01
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| Series: | Çocuk Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/8C6536A905D94F709742FE7E48353FC1 |
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| author | Aybüke Doğan Emine Ecem Aydoğan Hikmet Gülşah Tanyıldız |
| author_facet | Aybüke Doğan Emine Ecem Aydoğan Hikmet Gülşah Tanyıldız |
| author_sort | Aybüke Doğan |
| collection | DOAJ |
| description | Infantile hemangioma (IH) is the most common benign vascular tumor of the infantile period. Although the etiopathology of IH is not well-known, two primary theories exist. The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-1a), which leads to an increased production of vascular endothelial growth factor (VEGF), GLUT-1, and insulin-like growth factor-2, which induces endothelial cell proliferation. The second theory suggests that endothelial cell proliferation is induced by embolization of placental tissue. Propranolol is a nonselective beta-adrenergic receptor blocker which is used in current mainstay therapy for IH. In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level. |
| format | Article |
| id | doaj-art-1bcb3f8f5c6144899f3a42e6cad1d117 |
| institution | OA Journals |
| issn | 1308-8491 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Çocuk Dergisi |
| spelling | doaj-art-1bcb3f8f5c6144899f3a42e6cad1d1172025-08-20T01:51:06ZengIstanbul University PressÇocuk Dergisi1308-84912023-03-01231899410.26650/jchild.2023.878287123456Current Approach to The Treatment of Infantile HemangiomaAybüke Doğan0https://orcid.org/0000-0001-5014-3737Emine Ecem Aydoğan1https://orcid.org/0000-0003-2081-9227Hikmet Gülşah Tanyıldız2https://orcid.org/0000-0002-0455-2078İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeInfantile hemangioma (IH) is the most common benign vascular tumor of the infantile period. Although the etiopathology of IH is not well-known, two primary theories exist. The most accepted theory suggests that maternal hypoxic stress leads to the production of hypoxia inducible factor-1 alpha (HIF-1a), which leads to an increased production of vascular endothelial growth factor (VEGF), GLUT-1, and insulin-like growth factor-2, which induces endothelial cell proliferation. The second theory suggests that endothelial cell proliferation is induced by embolization of placental tissue. Propranolol is a nonselective beta-adrenergic receptor blocker which is used in current mainstay therapy for IH. In this review, we aimed to discuss the efficacy and safety of propranolol in light of current data, including studies at the molecular level.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/8C6536A905D94F709742FE7E48353FC1infantile hemangiomapropranololtopical timolol |
| spellingShingle | Aybüke Doğan Emine Ecem Aydoğan Hikmet Gülşah Tanyıldız Current Approach to The Treatment of Infantile Hemangioma Çocuk Dergisi infantile hemangioma propranolol topical timolol |
| title | Current Approach to The Treatment of Infantile Hemangioma |
| title_full | Current Approach to The Treatment of Infantile Hemangioma |
| title_fullStr | Current Approach to The Treatment of Infantile Hemangioma |
| title_full_unstemmed | Current Approach to The Treatment of Infantile Hemangioma |
| title_short | Current Approach to The Treatment of Infantile Hemangioma |
| title_sort | current approach to the treatment of infantile hemangioma |
| topic | infantile hemangioma propranolol topical timolol |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/8C6536A905D94F709742FE7E48353FC1 |
| work_keys_str_mv | AT aybukedogan currentapproachtothetreatmentofinfantilehemangioma AT emineecemaydogan currentapproachtothetreatmentofinfantilehemangioma AT hikmetgulsahtanyıldız currentapproachtothetreatmentofinfantilehemangioma |