tsRNA, cell death and disease: Connecting the dots
Cell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death. The relationship between tsRNAs and diseases has attracted growing attention. H...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-08-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054025000459 |
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| author | Xiaoyu Ma Jiesi Xu Guoping Li |
| author_facet | Xiaoyu Ma Jiesi Xu Guoping Li |
| author_sort | Xiaoyu Ma |
| collection | DOAJ |
| description | Cell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death. The relationship between tsRNAs and diseases has attracted growing attention. However, many challenges remain, particularly in understanding how tsRNAs regulate cell death and their newly discovered roles in these pathways. This paper reviews the generation and classification of tsRNAs and their roles in different diseases through cell death processes, such as ferroptosis, apoptosis, necroptosis, autophagy and pyroptosis. We discuss in detail the dysregulation of tsRNA expression in neurological disorders, metabolic diseases and cancer. We highlight the potential of tsRNAs as biomarkers and therapeutic targets in the context of cell death pathways. |
| format | Article |
| id | doaj-art-1bc9df9d96bd47a89aebb713e3435f2e |
| institution | Kabale University |
| issn | 2468-0540 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-1bc9df9d96bd47a89aebb713e3435f2e2025-08-20T03:33:06ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402025-08-011310912010.1016/j.ncrna.2025.04.006tsRNA, cell death and disease: Connecting the dotsXiaoyu Ma0Jiesi Xu1Guoping Li2The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR ChinaCorresponding author. No. 1, Dahua Road, Dongdan, Dongcheng District, Beijing 100730, PR China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR ChinaCorresponding author. No. 1, Dahua Road, Dongdan, Dongcheng District, Beijing 100730, PR China.; The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR ChinaCell death is essential for maintaining physiological homeostasis and regulating pathological processes. tRNA-derived small RNAs (tsRNAs), an emerging non-coding small RNA, play key roles in a various form of cell death. The relationship between tsRNAs and diseases has attracted growing attention. However, many challenges remain, particularly in understanding how tsRNAs regulate cell death and their newly discovered roles in these pathways. This paper reviews the generation and classification of tsRNAs and their roles in different diseases through cell death processes, such as ferroptosis, apoptosis, necroptosis, autophagy and pyroptosis. We discuss in detail the dysregulation of tsRNA expression in neurological disorders, metabolic diseases and cancer. We highlight the potential of tsRNAs as biomarkers and therapeutic targets in the context of cell death pathways.http://www.sciencedirect.com/science/article/pii/S2468054025000459tsRNACell deathFerroptosisNecroptosisPyroptosisApoptosis |
| spellingShingle | Xiaoyu Ma Jiesi Xu Guoping Li tsRNA, cell death and disease: Connecting the dots Non-coding RNA Research tsRNA Cell death Ferroptosis Necroptosis Pyroptosis Apoptosis |
| title | tsRNA, cell death and disease: Connecting the dots |
| title_full | tsRNA, cell death and disease: Connecting the dots |
| title_fullStr | tsRNA, cell death and disease: Connecting the dots |
| title_full_unstemmed | tsRNA, cell death and disease: Connecting the dots |
| title_short | tsRNA, cell death and disease: Connecting the dots |
| title_sort | tsrna cell death and disease connecting the dots |
| topic | tsRNA Cell death Ferroptosis Necroptosis Pyroptosis Apoptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2468054025000459 |
| work_keys_str_mv | AT xiaoyuma tsrnacelldeathanddiseaseconnectingthedots AT jiesixu tsrnacelldeathanddiseaseconnectingthedots AT guopingli tsrnacelldeathanddiseaseconnectingthedots |