Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia
Central nervous system (CNS) infections are relatively common among children receiving treatment for acute lymphoblastic leukemia (ALL). However, diagnosing these infections presents challenges. In this report, we present a case of asymptomatic adenoviral meningitis, which presented a diagnostic cha...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2025-04-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801886 |
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| author | Swetha Palla Parikshaa Gupta Amita Trehan |
| author_facet | Swetha Palla Parikshaa Gupta Amita Trehan |
| author_sort | Swetha Palla |
| collection | DOAJ |
| description | Central nervous system (CNS) infections are relatively common among children receiving treatment for acute lymphoblastic leukemia (ALL). However, diagnosing these infections presents challenges. In this report, we present a case of asymptomatic adenoviral meningitis, which presented a diagnostic challenge as it mimicked CNS involvement in a child undergoing treatment for ALL. Our findings underscore the importance of thorough diagnostic evaluation for CNS infections in children undergoing ALL therapy, whether they present with symptoms or exhibit asymptomatic cerebrospinal fluid pleocytosis. Furthermore, distinguishing between infections and CNS leukemia is critical, highlighting the necessity of employing flow cytometry to mitigate the potential misinterpretation of morphological features. |
| format | Article |
| id | doaj-art-1bc7ed99d9a643f89553785ebe814c60 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-1bc7ed99d9a643f89553785ebe814c602025-08-20T02:22:34ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292025-04-01460221121310.1055/s-0045-1801886Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic LeukemiaSwetha Palla0https://orcid.org/0000-0002-7053-5866Parikshaa Gupta1Amita Trehan2Pediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Cytology and Gynaecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaPediatric Hematology-Oncology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaCentral nervous system (CNS) infections are relatively common among children receiving treatment for acute lymphoblastic leukemia (ALL). However, diagnosing these infections presents challenges. In this report, we present a case of asymptomatic adenoviral meningitis, which presented a diagnostic challenge as it mimicked CNS involvement in a child undergoing treatment for ALL. Our findings underscore the importance of thorough diagnostic evaluation for CNS infections in children undergoing ALL therapy, whether they present with symptoms or exhibit asymptomatic cerebrospinal fluid pleocytosis. Furthermore, distinguishing between infections and CNS leukemia is critical, highlighting the necessity of employing flow cytometry to mitigate the potential misinterpretation of morphological features.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801886acute lymphoblastic leukemiaCSF pleocytosisCNS infectionCNS leukemia. |
| spellingShingle | Swetha Palla Parikshaa Gupta Amita Trehan Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia Indian Journal of Medical and Paediatric Oncology acute lymphoblastic leukemia CSF pleocytosis CNS infection CNS leukemia. |
| title | Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia |
| title_full | Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia |
| title_fullStr | Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia |
| title_short | Catch-22 Situation with Unexpected Reports in Acute Lymphoblastic Leukemia |
| title_sort | catch 22 situation with unexpected reports in acute lymphoblastic leukemia |
| topic | acute lymphoblastic leukemia CSF pleocytosis CNS infection CNS leukemia. |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1801886 |
| work_keys_str_mv | AT swethapalla catch22situationwithunexpectedreportsinacutelymphoblasticleukemia AT parikshaagupta catch22situationwithunexpectedreportsinacutelymphoblasticleukemia AT amitatrehan catch22situationwithunexpectedreportsinacutelymphoblasticleukemia |