Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease
An increased risk of developing Alzheimer’s disease (AD) exists in patients with a history of depression. In the present study, we demonstrated that chronic agomelatine intraperitoneal treatment, at a dose of 40 mg/ kg for 21 days, starting one month after inducing AD by intracerebroventricular inje...
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| Format: | Article |
| Language: | English |
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Medical University - Pleven
2020-12-01
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| Series: | Journal of Biomedical & Clinical Research |
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| Online Access: | https://jbcr.arphahub.com/article/34582/download/pdf/ |
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| author | Kalina Ilieva Jana Tchekalarova Milena Atanasova Lidiya Petrova |
| author_facet | Kalina Ilieva Jana Tchekalarova Milena Atanasova Lidiya Petrova |
| author_sort | Kalina Ilieva |
| collection | DOAJ |
| description | An increased risk of developing Alzheimer’s disease (AD) exists in patients with a history of depression. In the present study, we demonstrated that chronic agomelatine intraperitoneal treatment, at a dose of 40 mg/ kg for 21 days, starting one month after inducing AD by intracerebroventricular injection of amyloid-beta (Aβ) corrected anhedonia, decreased anxiety, and showed a potential to mitigate working memory errors during the last session in a radial arm maze. Altogether, our findings suggest that chronic agomelatine administration treatment could alleviate the burden of AD and may be considered a promising therapeutic approach to some adverse symptoms caused by the disease. |
| format | Article |
| id | doaj-art-1bc63747b22f42008cf60b796ae2d150 |
| institution | DOAJ |
| issn | 1313-9053 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-1bc63747b22f42008cf60b796ae2d1502025-08-20T03:13:42ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532020-12-0113211612110.2478/jbcr-2020-001634582Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s DiseaseKalina IlievaJana TchekalarovaMilena AtanasovaLidiya PetrovaAn increased risk of developing Alzheimer’s disease (AD) exists in patients with a history of depression. In the present study, we demonstrated that chronic agomelatine intraperitoneal treatment, at a dose of 40 mg/ kg for 21 days, starting one month after inducing AD by intracerebroventricular injection of amyloid-beta (Aβ) corrected anhedonia, decreased anxiety, and showed a potential to mitigate working memory errors during the last session in a radial arm maze. Altogether, our findings suggest that chronic agomelatine administration treatment could alleviate the burden of AD and may be considered a promising therapeutic approach to some adverse symptoms caused by the disease.https://jbcr.arphahub.com/article/34582/download/pdf/Alzheimer’s diseaseamyloid-betaagomelatinede |
| spellingShingle | Kalina Ilieva Jana Tchekalarova Milena Atanasova Lidiya Petrova Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease Journal of Biomedical & Clinical Research Alzheimer’s disease amyloid-beta agomelatine de |
| title | Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease |
| title_full | Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease |
| title_fullStr | Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease |
| title_full_unstemmed | Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease |
| title_short | Beneficial Influence of Agomelatine Treatment on Behavioral Impairments in AΒ-Induced Rat Model of Alzheimer’s Disease |
| title_sort | beneficial influence of agomelatine treatment on behavioral impairments in aβ induced rat model of alzheimer s disease |
| topic | Alzheimer’s disease amyloid-beta agomelatine de |
| url | https://jbcr.arphahub.com/article/34582/download/pdf/ |
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