Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

<h4>Background</h4>Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cancers.<h4>Method...

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Main Authors: Barbara Jung, Jessica Gomez, Eddy Chau, Jennifer Cabral, Jeffrey K Lee, Aimee Anselm, Przemyslaw Slowik, Deena Ream-Robinson, Karen Messer, Judith Sporn, Sung K Shin, C Richard Boland, Ajay Goel, John M Carethers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008308&type=printable
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