The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy
Purpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/2439691 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559471114584064 |
|---|---|
| author | Azusa Ito Hiroshi Kunikata Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Kazuki Hashimoto Naoko Aizawa Hideki Katagiri Toru Nakazawa |
| author_facet | Azusa Ito Hiroshi Kunikata Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Kazuki Hashimoto Naoko Aizawa Hideki Katagiri Toru Nakazawa |
| author_sort | Azusa Ito |
| collection | DOAJ |
| description | Purpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results. Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P=0.008 and P=0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P=0.012 and OR 0.69 P=0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P=0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P=0.035, P=0.015, and P=0.008, resp.). Conclusions. Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR. |
| format | Article |
| id | doaj-art-1bc059338c50448e8ca27f8ce78e1c94 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-1bc059338c50448e8ca27f8ce78e1c942025-02-03T01:29:54ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/24396912439691The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic RetinopathyAzusa Ito0Hiroshi Kunikata1Masayuki Yasuda2Shojiro Sawada3Keiichi Kondo4Chihiro Satake5Kazuki Hashimoto6Naoko Aizawa7Hideki Katagiri8Toru Nakazawa9Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, JapanPurpose. Nerve conduction velocity (NCV) is an indicator of neuronal damage in the distal segment of the peripheral nerves. Here, we determined the association between NCV and other systemic and ocular clinical findings, in type 2 diabetes patients with early diabetic retinopathy (DR). Methods. This study included 42 eyes of 42 type 2 diabetes patients (median age: 54 years) with no DR or with mild nonproliferative DR. Standard statistical techniques were used to determine associations between clinical findings. Results. Sural sensory conduction velocity (SCV) and tibial motor conduction velocity (MCV) were significantly lower in mild nonproliferative DR patients than patients with no DR (P=0.008 and P=0.01, resp.). Furthermore, logistic regression analyses revealed that sural SCV and tibial MCV were independent factors contributing to the presence of mild nonproliferative DR (OR 0.83, P=0.012 and OR 0.69 P=0.02, resp.). Tibial MCV was correlated with choroidal thickness (CT) (P=0.01), and a multiple regression analysis revealed that age, tibial MCV, and carotid intima-media thickness were independent associating factors with CT (P=0.035, P=0.015, and P=0.008, resp.). Conclusions. Our findings suggest that reduced NCV may be closely associated with early DR in type 2 diabetes patients. Thus, reduced nerve conduction is a potential early biomarker of DR.http://dx.doi.org/10.1155/2018/2439691 |
| spellingShingle | Azusa Ito Hiroshi Kunikata Masayuki Yasuda Shojiro Sawada Keiichi Kondo Chihiro Satake Kazuki Hashimoto Naoko Aizawa Hideki Katagiri Toru Nakazawa The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy Journal of Ophthalmology |
| title | The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy |
| title_full | The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy |
| title_fullStr | The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy |
| title_full_unstemmed | The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy |
| title_short | The Relationship between Peripheral Nerve Conduction Velocity and Ophthalmological Findings in Type 2 Diabetes Patients with Early Diabetic Retinopathy |
| title_sort | relationship between peripheral nerve conduction velocity and ophthalmological findings in type 2 diabetes patients with early diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2018/2439691 |
| work_keys_str_mv | AT azusaito therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT hiroshikunikata therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT masayukiyasuda therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT shojirosawada therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT keiichikondo therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT chihirosatake therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT kazukihashimoto therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT naokoaizawa therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT hidekikatagiri therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT torunakazawa therelationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT azusaito relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT hiroshikunikata relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT masayukiyasuda relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT shojirosawada relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT keiichikondo relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT chihirosatake relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT kazukihashimoto relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT naokoaizawa relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT hidekikatagiri relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy AT torunakazawa relationshipbetweenperipheralnerveconductionvelocityandophthalmologicalfindingsintype2diabetespatientswithearlydiabeticretinopathy |