The prognosis of patients with myocardial infarction after light therapy: A preliminary study
Background: Patients with myocardial infarction (MI) can have disturbed sleep, but little is known about the efficacy of light therapy on sleep and the prognosis of patients with MI. We conducted a randomized controlled study to investigate its efficacy. Material and methods: This preliminary study...
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Elsevier
2025-06-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417024000866 |
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| author | Wei-Chih Chin Yu-Shu Huang Lung-Sheng Wu Kuang-Tso Lee Chien-Te Ho Chen Lin Wei-Sheng Yang I-Hang Chung Pao-Hsien Chu |
| author_facet | Wei-Chih Chin Yu-Shu Huang Lung-Sheng Wu Kuang-Tso Lee Chien-Te Ho Chen Lin Wei-Sheng Yang I-Hang Chung Pao-Hsien Chu |
| author_sort | Wei-Chih Chin |
| collection | DOAJ |
| description | Background: Patients with myocardial infarction (MI) can have disturbed sleep, but little is known about the efficacy of light therapy on sleep and the prognosis of patients with MI. We conducted a randomized controlled study to investigate its efficacy. Material and methods: This preliminary study included 34 patients with MI. They were randomized into the blue light and the white light groups during their stay in intensive care unit. 17 age and gender-matched healthy controls were also enrolled. Actigraphy was used to evaluate objective sleep since enrollment. Delirium scales were used to screen delirium. Lab work-up, including vitamin D level was performed at the baseline and discharge. We used the Mann-Whitney U test or Wilcoxon signed-rank test to compare the difference between the MI group and the healthy control group, and the group difference after receiving light therapy. Results: Patients with MI had significantly lower vitamin D levels than healthy controls (p < 0.001). They also had significantly poorer sleep, as indicated by actigraphy parameters, including sleep onset latency (p = 0.01), sleep efficiency (p = 0.002), wake after sleep onset (p < 0.001), and awake times (p = 0.002). No significant group difference was found by actigraphy after light therapy except a non-significant higher relative amplitude of the blue light group (p = 0.061). Besides, the vitamin D level of the blue light group increased significantly (p1 = 0.047, p2 = 0.045). Conclusions: Patients with MI had poorer sleep, highlighting the need to develop interventions. Significantly increased vitamin D levels and a non-significant better rest-active rhythm after light therapy suggest its potential with sleep and prognosis, which warrants further investigation. |
| format | Article |
| id | doaj-art-1bbe2ad7cb514e91a09451fc0ad68240 |
| institution | DOAJ |
| issn | 2319-4170 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj-art-1bbe2ad7cb514e91a09451fc0ad682402025-08-20T02:44:51ZengElsevierBiomedical Journal2319-41702025-06-0148310078310.1016/j.bj.2024.100783The prognosis of patients with myocardial infarction after light therapy: A preliminary studyWei-Chih Chin0Yu-Shu Huang1Lung-Sheng Wu2Kuang-Tso Lee3Chien-Te Ho4Chen Lin5Wei-Sheng Yang6I-Hang Chung7Pao-Hsien Chu8Division of Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; College of Life Sciences and Medicine, National Tsing Hua University, Hsinchu, TaiwanDivision of Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Cardiology, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Cardiology, Chang Gung Memorial Hospital, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Cardiology, Chang Gung Memorial Hospital, Taoyuan, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan, TaiwanDepartment of Psychiatry, New Taipei City Tucheng Hospital, New Taipei City, TaiwanDivision of Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Corresponding author. Department of Cardiology, Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan, Taoyuan, 333, Taiwan.Background: Patients with myocardial infarction (MI) can have disturbed sleep, but little is known about the efficacy of light therapy on sleep and the prognosis of patients with MI. We conducted a randomized controlled study to investigate its efficacy. Material and methods: This preliminary study included 34 patients with MI. They were randomized into the blue light and the white light groups during their stay in intensive care unit. 17 age and gender-matched healthy controls were also enrolled. Actigraphy was used to evaluate objective sleep since enrollment. Delirium scales were used to screen delirium. Lab work-up, including vitamin D level was performed at the baseline and discharge. We used the Mann-Whitney U test or Wilcoxon signed-rank test to compare the difference between the MI group and the healthy control group, and the group difference after receiving light therapy. Results: Patients with MI had significantly lower vitamin D levels than healthy controls (p < 0.001). They also had significantly poorer sleep, as indicated by actigraphy parameters, including sleep onset latency (p = 0.01), sleep efficiency (p = 0.002), wake after sleep onset (p < 0.001), and awake times (p = 0.002). No significant group difference was found by actigraphy after light therapy except a non-significant higher relative amplitude of the blue light group (p = 0.061). Besides, the vitamin D level of the blue light group increased significantly (p1 = 0.047, p2 = 0.045). Conclusions: Patients with MI had poorer sleep, highlighting the need to develop interventions. Significantly increased vitamin D levels and a non-significant better rest-active rhythm after light therapy suggest its potential with sleep and prognosis, which warrants further investigation.http://www.sciencedirect.com/science/article/pii/S2319417024000866Myocardial infarctionLight therapySleepActigraphyVitamin D |
| spellingShingle | Wei-Chih Chin Yu-Shu Huang Lung-Sheng Wu Kuang-Tso Lee Chien-Te Ho Chen Lin Wei-Sheng Yang I-Hang Chung Pao-Hsien Chu The prognosis of patients with myocardial infarction after light therapy: A preliminary study Biomedical Journal Myocardial infarction Light therapy Sleep Actigraphy Vitamin D |
| title | The prognosis of patients with myocardial infarction after light therapy: A preliminary study |
| title_full | The prognosis of patients with myocardial infarction after light therapy: A preliminary study |
| title_fullStr | The prognosis of patients with myocardial infarction after light therapy: A preliminary study |
| title_full_unstemmed | The prognosis of patients with myocardial infarction after light therapy: A preliminary study |
| title_short | The prognosis of patients with myocardial infarction after light therapy: A preliminary study |
| title_sort | prognosis of patients with myocardial infarction after light therapy a preliminary study |
| topic | Myocardial infarction Light therapy Sleep Actigraphy Vitamin D |
| url | http://www.sciencedirect.com/science/article/pii/S2319417024000866 |
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