Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania
<b>Background and Objectives:</b> As a leading European country in terms of cervical cancer incidence and mortality, there has been a pressing need for Romania to upgrade its cervical cancer management. The criteria set by the International Federation of Gynecology and Obstetrics indicat...
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MDPI AG
2025-06-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/6/336 |
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| author | Ion Petre Șerban Mircea Negru Florina Buleu Radu Dumitru Moleriu Marina Adriana Mercioni Izabella Petre Anca Bordianu Vladiana Turi Luciana Marc Daian Ionel Popa Daliborca Cristina Vlad |
| author_facet | Ion Petre Șerban Mircea Negru Florina Buleu Radu Dumitru Moleriu Marina Adriana Mercioni Izabella Petre Anca Bordianu Vladiana Turi Luciana Marc Daian Ionel Popa Daliborca Cristina Vlad |
| author_sort | Ion Petre |
| collection | DOAJ |
| description | <b>Background and Objectives:</b> As a leading European country in terms of cervical cancer incidence and mortality, there has been a pressing need for Romania to upgrade its cervical cancer management. The criteria set by the International Federation of Gynecology and Obstetrics indicate that different treatments should have a similar trend concerning progression-free survival and overall survival at all the various stages of cervical cancer. This study aimed to assess the cost-effectiveness (CE) of the primary treatment plans related to the survival rate for cervical cancer screening in the western part of Romania and provide some recommendations. <b>Materials and Methods:</b> Descriptive statistics and a correlation model were used to examine costs. AI models have been developed to forecast the CE of different treatments using the above-mentioned studies on overall survival rates and treatment-related toxicity rates for five years. The costs of cervical cancer treatment were sourced from the public health department, the oncology clinic in the western region of Romania, and the County Hospital available for each stage. <b>Results:</b> Treatment expenses vary by cancer stage, with a significant increase from stages IA/IB to IIA, stabilizing between IIA and IIIC (about €7800–€8300), followed by a steep decline in IVA and a more pronounced decrease in IVB and in situ. The results highlight certain treatment combinations and their costs, indicating that the highest costs (exceeding €8000) are linked to multimodal treatments, which encompass surgery, chemotherapy, radiotherapy, and brachytherapy. <b>Conclusions</b>: Advanced cancer stages (IIA–IIIC) entail the highest treatment costs due to intricate, multimodal therapy, whereas early stages (IA, IB, in situ) and late terminal stages (IVB) are linked to considerably reduced treatment costs. |
| format | Article |
| id | doaj-art-1bb912fc69b44f839d05172b8a89f6de |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-1bb912fc69b44f839d05172b8a89f6de2025-08-20T03:27:23ZengMDPI AGCurrent Oncology1198-00521718-77292025-06-0132633610.3390/curroncol32060336Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western RomaniaIon Petre0Șerban Mircea Negru1Florina Buleu2Radu Dumitru Moleriu3Marina Adriana Mercioni4Izabella Petre5Anca Bordianu6Vladiana Turi7Luciana Marc8Daian Ionel Popa9Daliborca Cristina Vlad10Doctoral School, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Oncology, “Victor Babes” University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, RomaniaDepartment of Cardiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, RomaniaDepartment of Functional Sciences, Medical Informatics and Biostatistics Discipline, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania“Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, RomaniaDepartment XII of Obstetrics and Gynaecology, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Plastic Surgery and Reconstructive Microsurgery “Bagdasar-Arseni” Emergency Hospital Bucharest, University of Medicine and Pharmacy “Carol Davila”, 010825 Bucharest, RomaniaDepartment of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, RomaniaDepartment VII of Internal Medicine II, Division of Nephrology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, RomaniaDoctoral School, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Biochemistry and Pharmacology, “Victor Babes” University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania<b>Background and Objectives:</b> As a leading European country in terms of cervical cancer incidence and mortality, there has been a pressing need for Romania to upgrade its cervical cancer management. The criteria set by the International Federation of Gynecology and Obstetrics indicate that different treatments should have a similar trend concerning progression-free survival and overall survival at all the various stages of cervical cancer. This study aimed to assess the cost-effectiveness (CE) of the primary treatment plans related to the survival rate for cervical cancer screening in the western part of Romania and provide some recommendations. <b>Materials and Methods:</b> Descriptive statistics and a correlation model were used to examine costs. AI models have been developed to forecast the CE of different treatments using the above-mentioned studies on overall survival rates and treatment-related toxicity rates for five years. The costs of cervical cancer treatment were sourced from the public health department, the oncology clinic in the western region of Romania, and the County Hospital available for each stage. <b>Results:</b> Treatment expenses vary by cancer stage, with a significant increase from stages IA/IB to IIA, stabilizing between IIA and IIIC (about €7800–€8300), followed by a steep decline in IVA and a more pronounced decrease in IVB and in situ. The results highlight certain treatment combinations and their costs, indicating that the highest costs (exceeding €8000) are linked to multimodal treatments, which encompass surgery, chemotherapy, radiotherapy, and brachytherapy. <b>Conclusions</b>: Advanced cancer stages (IIA–IIIC) entail the highest treatment costs due to intricate, multimodal therapy, whereas early stages (IA, IB, in situ) and late terminal stages (IVB) are linked to considerably reduced treatment costs.https://www.mdpi.com/1718-7729/32/6/336cost-effectivenesscervical cancertreatmentsurgerycancer screening |
| spellingShingle | Ion Petre Șerban Mircea Negru Florina Buleu Radu Dumitru Moleriu Marina Adriana Mercioni Izabella Petre Anca Bordianu Vladiana Turi Luciana Marc Daian Ionel Popa Daliborca Cristina Vlad Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania Current Oncology cost-effectiveness cervical cancer treatment surgery cancer screening |
| title | Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania |
| title_full | Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania |
| title_fullStr | Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania |
| title_full_unstemmed | Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania |
| title_short | Evaluating the Cost-Effectiveness of Cervical Cancer Screening and Treatment in Western Romania |
| title_sort | evaluating the cost effectiveness of cervical cancer screening and treatment in western romania |
| topic | cost-effectiveness cervical cancer treatment surgery cancer screening |
| url | https://www.mdpi.com/1718-7729/32/6/336 |
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