Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation.
The time scale of neuronal network dynamics is determined by synaptic interactions and neuronal signal integration, both of which occur on the time scale of milliseconds. Yet many behaviors like the generation of movements or vocalizations of sounds occur on the much slower time scale of seconds. He...
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Public Library of Science (PLoS)
2018-07-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006216&type=printable |
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| author | Hesam Setareh Moritz Deger Wulfram Gerstner |
| author_facet | Hesam Setareh Moritz Deger Wulfram Gerstner |
| author_sort | Hesam Setareh |
| collection | DOAJ |
| description | The time scale of neuronal network dynamics is determined by synaptic interactions and neuronal signal integration, both of which occur on the time scale of milliseconds. Yet many behaviors like the generation of movements or vocalizations of sounds occur on the much slower time scale of seconds. Here we ask the question of how neuronal networks of the brain can support reliable behavior on this time scale. We argue that excitable neuronal assemblies with spike-frequency adaptation may serve as building blocks that can flexibly adjust the speed of execution of neural circuit function. We show in simulations that a chain of neuronal assemblies can propagate signals reliably, similar to the well-known synfire chain, but with the crucial difference that the propagation speed is slower and tunable to the behaviorally relevant range. Moreover we study a grid of excitable neuronal assemblies as a simplified model of the somatosensory barrel cortex of the mouse and demonstrate that various patterns of experimentally observed spatial activity propagation can be explained. |
| format | Article |
| id | doaj-art-1bb755df8a0745008bf46bc531521865 |
| institution | DOAJ |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2018-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-1bb755df8a0745008bf46bc5315218652025-08-20T03:11:25ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582018-07-01147e100621610.1371/journal.pcbi.1006216Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation.Hesam SetarehMoritz DegerWulfram GerstnerThe time scale of neuronal network dynamics is determined by synaptic interactions and neuronal signal integration, both of which occur on the time scale of milliseconds. Yet many behaviors like the generation of movements or vocalizations of sounds occur on the much slower time scale of seconds. Here we ask the question of how neuronal networks of the brain can support reliable behavior on this time scale. We argue that excitable neuronal assemblies with spike-frequency adaptation may serve as building blocks that can flexibly adjust the speed of execution of neural circuit function. We show in simulations that a chain of neuronal assemblies can propagate signals reliably, similar to the well-known synfire chain, but with the crucial difference that the propagation speed is slower and tunable to the behaviorally relevant range. Moreover we study a grid of excitable neuronal assemblies as a simplified model of the somatosensory barrel cortex of the mouse and demonstrate that various patterns of experimentally observed spatial activity propagation can be explained.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006216&type=printable |
| spellingShingle | Hesam Setareh Moritz Deger Wulfram Gerstner Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. PLoS Computational Biology |
| title | Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. |
| title_full | Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. |
| title_fullStr | Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. |
| title_full_unstemmed | Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. |
| title_short | Excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity-controlled signal propagation. |
| title_sort | excitable neuronal assemblies with adaptation as a building block of brain circuits for velocity controlled signal propagation |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1006216&type=printable |
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