A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/2431503 |
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| author | Behdod Poushanchi Hiren Vallabh Gorman Joel Reynolds |
| author_facet | Behdod Poushanchi Hiren Vallabh Gorman Joel Reynolds |
| author_sort | Behdod Poushanchi |
| collection | DOAJ |
| description | Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy. |
| format | Article |
| id | doaj-art-1baa61e105a049e1870c66447b3ed8d6 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-1baa61e105a049e1870c66447b3ed8d62025-02-03T05:58:18ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362018-01-01201810.1155/2018/24315032431503A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and InfliximabBehdod Poushanchi0Hiren Vallabh1Gorman Joel Reynolds2Department of Medicine, West Virginia University, Morgantown, WV, USADivision of Gastroenterology, West Virginia University, Morgantown, WV, USADivision of Gastroenterology, West Virginia University, Morgantown, WV, USAIpilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy.http://dx.doi.org/10.1155/2018/2431503 |
| spellingShingle | Behdod Poushanchi Hiren Vallabh Gorman Joel Reynolds A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab Case Reports in Gastrointestinal Medicine |
| title | A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab |
| title_full | A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab |
| title_fullStr | A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab |
| title_full_unstemmed | A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab |
| title_short | A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab |
| title_sort | severe case of ipilimumab induced ileocolitis refractory to glucocorticosteroids and infliximab |
| url | http://dx.doi.org/10.1155/2018/2431503 |
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