Discovery of a parallel family of euglenatide analogs in Euglena gracilis
Abstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae pro...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-01-01
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| Series: | Natural Products and Bioprospecting |
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| Online Access: | https://doi.org/10.1007/s13659-024-00490-8 |
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| author | Ahmed H. Elbanna Xinhui Kou Dilip V. Prajapati Surasree Rakshit Rebecca A. Butcher |
| author_facet | Ahmed H. Elbanna Xinhui Kou Dilip V. Prajapati Surasree Rakshit Rebecca A. Butcher |
| author_sort | Ahmed H. Elbanna |
| collection | DOAJ |
| description | Abstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides. Graphical abstract |
| format | Article |
| id | doaj-art-1ba84b076299488f98e4366a7a27e7c5 |
| institution | Kabale University |
| issn | 2192-2195 2192-2209 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Natural Products and Bioprospecting |
| spelling | doaj-art-1ba84b076299488f98e4366a7a27e7c52025-01-12T12:44:35ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092025-01-0115111010.1007/s13659-024-00490-8Discovery of a parallel family of euglenatide analogs in Euglena gracilisAhmed H. Elbanna0Xinhui Kou1Dilip V. Prajapati2Surasree Rakshit3Rebecca A. Butcher4Department of Chemistry, University of FloridaDepartment of Chemistry, University of FloridaDepartment of Chemistry, University of FloridaDepartment of Chemistry, University of FloridaDepartment of Chemistry, University of FloridaAbstract The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides. Graphical abstracthttps://doi.org/10.1007/s13659-024-00490-8Euglena gracilisEuglenatideNatural productsPolyketideNonribosomal peptide |
| spellingShingle | Ahmed H. Elbanna Xinhui Kou Dilip V. Prajapati Surasree Rakshit Rebecca A. Butcher Discovery of a parallel family of euglenatide analogs in Euglena gracilis Natural Products and Bioprospecting Euglena gracilis Euglenatide Natural products Polyketide Nonribosomal peptide |
| title | Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| title_full | Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| title_fullStr | Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| title_full_unstemmed | Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| title_short | Discovery of a parallel family of euglenatide analogs in Euglena gracilis |
| title_sort | discovery of a parallel family of euglenatide analogs in euglena gracilis |
| topic | Euglena gracilis Euglenatide Natural products Polyketide Nonribosomal peptide |
| url | https://doi.org/10.1007/s13659-024-00490-8 |
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