Carbapenem-resistant Gram-negative bacteria exhibiting clinically undetected cefiderocol heteroresistance leads to treatment failure in a murine model of infection

Carbapenem-resistant Gram-negative bacteria exhibiting clinically undetected cefiderocol heteroresistance leads to treatment failure in a murine model of infection

IntroductionCarbapenem-resistant (CR) Gram-negative pathogens are classified by the WHO as critical threats due to limited therapeutic options. Cefiderocol (CFD), a novel siderophore cephalosporin, shows promise but remains unapproved in China. This study investigated the prevalence, clinical impact...

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Bibliographic Details
Main Authors: Hongwei Liu, Peng Zhou, Peng Ma, Yaqin Liu, Yingfeng Zhang, Qiwei Li, Lingqing Xu, Wenchang Yuan, Weiguo Yin, Linhai Li, Yang Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Microbiology
Subjects:
heteroresistance
cefiderocol
gene mutation
failure treatment
carbapenem resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1496514/full
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