Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.
<h4>Objective</h4>Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high bloo...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112569&type=printable |
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| author | Jeffrey B Schwimmer Anne Zepeda Kimberly P Newton Stavra A Xanthakos Cynthia Behling Erin K Hallinan Michele Donithan James Tonascia Nonalcoholic Steatohepatitis Clinical Research Network |
| author_facet | Jeffrey B Schwimmer Anne Zepeda Kimberly P Newton Stavra A Xanthakos Cynthia Behling Erin K Hallinan Michele Donithan James Tonascia Nonalcoholic Steatohepatitis Clinical Research Network |
| author_sort | Jeffrey B Schwimmer |
| collection | DOAJ |
| description | <h4>Objective</h4>Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD.<h4>Methods</h4>Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks.<h4>Results</h4>Prevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P = 0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P = 0.05).<h4>Conclusions</h4>In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD. |
| format | Article |
| id | doaj-art-1ba2c3760aff4a088e7da7d7cf2f1af7 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-1ba2c3760aff4a088e7da7d7cf2f1af72025-08-20T03:01:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11256910.1371/journal.pone.0112569Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease.Jeffrey B SchwimmerAnne ZepedaKimberly P NewtonStavra A XanthakosCynthia BehlingErin K HallinanMichele DonithanJames TonasciaNonalcoholic Steatohepatitis Clinical Research Network<h4>Objective</h4>Nonalcoholic fatty liver disease (NAFLD) affects 9.6% of children and may put these children at elevated risk of high blood pressure and subsequent cardiovascular morbidity and mortality. Therefore, we sought to determine the prevalence of and risk factors for high blood pressure in children with NAFLD.<h4>Methods</h4>Cohort study performed by the NIDDK NASH Clinical Research Network. There were 484 children with NAFLD ages 2 to 17 at enrollment; 382 children were assessed both at enrollment and 48 weeks afterwards. The main outcomes were high blood pressure at baseline and persistent high blood pressure at both baseline and 48 weeks.<h4>Results</h4>Prevalence of high blood pressure at baseline was 35.8% and prevalence of persistent high blood pressure was 21.4%. Children with high blood pressure were significantly more likely to have worse steatosis than children without high blood pressure (mild 19.8% vs. 34.2%, moderate 35.0% vs. 30.7%, severe 45.2% vs. 35.1%; P = 0.003). Higher body mass index, low-density lipoprotein, and uric acid were independent risk factors for high blood pressure (Odds Ratios: 1.10 per kg/m2, 1.09 per 10 mg/dL, 1.25 per mg/dL, respectively). Compared to boys, girls with NAFLD were significantly more likely to have persistent high blood pressure (28.4% vs.18.9%; P = 0.05).<h4>Conclusions</h4>In conclusion, NAFLD is a common clinical problem that places children at substantial risk for high blood pressure, which may often go undiagnosed. Thus blood pressure evaluation, control, and monitoring should be an integral component of the clinical management of children with NAFLD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112569&type=printable |
| spellingShingle | Jeffrey B Schwimmer Anne Zepeda Kimberly P Newton Stavra A Xanthakos Cynthia Behling Erin K Hallinan Michele Donithan James Tonascia Nonalcoholic Steatohepatitis Clinical Research Network Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. PLoS ONE |
| title | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. |
| title_full | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. |
| title_fullStr | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. |
| title_full_unstemmed | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. |
| title_short | Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. |
| title_sort | longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112569&type=printable |
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