Role of TRPV1 in neuroendocrine regulation: a potential target against obesity?
Obesity is a common metabolic syndrome in which an imbalance between energy intake and consumption is the main cause of excessive accumulation of body fat. The increasing prevalence of obesity and its associated complications poses significant challenges to public health. Activation of the transient...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598804/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849710264572706816 |
|---|---|
| author | Jiexin Wang Maohui Liu Lingmiao Wen Pengfei Xing Jiawei Chen Xiuwen Xia WeiJun Ding |
| author_facet | Jiexin Wang Maohui Liu Lingmiao Wen Pengfei Xing Jiawei Chen Xiuwen Xia WeiJun Ding |
| author_sort | Jiexin Wang |
| collection | DOAJ |
| description | Obesity is a common metabolic syndrome in which an imbalance between energy intake and consumption is the main cause of excessive accumulation of body fat. The increasing prevalence of obesity and its associated complications poses significant challenges to public health. Activation of the transient receptor potential vanilloid subtype 1 (TRPV1) cascade plays a key role in lipid metabolism and energy intake. TRPV1 is expressed across the central nervous system and peripheral organs is involved in the regulation of hormone secretion, appetite and mitochondrial function, and is recognized as one of the key targets for preventing obesity. The current treatments for obesity exhibit limited efficacy and are associated with numerous side effects. Targeting TRPV1 represents a potentially effective approach for managing obesity. In this work, by combining the recent mechanism of the role of TRPV1 in neuroendocrine regulation, we hope to provide novel approaches to block or even reverse the development of obesity. |
| format | Article |
| id | doaj-art-1ba10aef83b74bbbadfd9b16e05c1ee1 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1ba10aef83b74bbbadfd9b16e05c1ee12025-08-20T03:14:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.15988041598804Role of TRPV1 in neuroendocrine regulation: a potential target against obesity?Jiexin WangMaohui LiuLingmiao WenPengfei XingJiawei ChenXiuwen XiaWeiJun DingObesity is a common metabolic syndrome in which an imbalance between energy intake and consumption is the main cause of excessive accumulation of body fat. The increasing prevalence of obesity and its associated complications poses significant challenges to public health. Activation of the transient receptor potential vanilloid subtype 1 (TRPV1) cascade plays a key role in lipid metabolism and energy intake. TRPV1 is expressed across the central nervous system and peripheral organs is involved in the regulation of hormone secretion, appetite and mitochondrial function, and is recognized as one of the key targets for preventing obesity. The current treatments for obesity exhibit limited efficacy and are associated with numerous side effects. Targeting TRPV1 represents a potentially effective approach for managing obesity. In this work, by combining the recent mechanism of the role of TRPV1 in neuroendocrine regulation, we hope to provide novel approaches to block or even reverse the development of obesity.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598804/fulltransient receptor potential vanilloid subtype 1 (TRPV1)obesityneuromodulatory mechanismsendocrine mechanismsenergy metabolism |
| spellingShingle | Jiexin Wang Maohui Liu Lingmiao Wen Pengfei Xing Jiawei Chen Xiuwen Xia WeiJun Ding Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? Frontiers in Immunology transient receptor potential vanilloid subtype 1 (TRPV1) obesity neuromodulatory mechanisms endocrine mechanisms energy metabolism |
| title | Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? |
| title_full | Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? |
| title_fullStr | Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? |
| title_full_unstemmed | Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? |
| title_short | Role of TRPV1 in neuroendocrine regulation: a potential target against obesity? |
| title_sort | role of trpv1 in neuroendocrine regulation a potential target against obesity |
| topic | transient receptor potential vanilloid subtype 1 (TRPV1) obesity neuromodulatory mechanisms endocrine mechanisms energy metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598804/full |
| work_keys_str_mv | AT jiexinwang roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT maohuiliu roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT lingmiaowen roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT pengfeixing roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT jiaweichen roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT xiuwenxia roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity AT weijunding roleoftrpv1inneuroendocrineregulationapotentialtargetagainstobesity |