Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment
Relevance: Arterial hypertension (HTN) in kidney transplant recipients is a major risk factor for cardiovascular diseases, graft rejection and premature death. In the post-transplant period in 80% of cases persistent or refractory arterial hypertension develops which is difficult to correct with con...
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| Format: | Article |
| Language: | Russian |
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Private institution educational organization of higher education "Medical University "ReaViz"
2024-06-01
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| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
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| Online Access: | https://vestnik.reaviz.ru/jour/article/view/981 |
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| author | M. Sh. Khubutiya F. M. Musaeva T. A. Kanunova O. N. Rzhevskaya A. G. Balkarov Kh. G. Alidzhanova |
| author_facet | M. Sh. Khubutiya F. M. Musaeva T. A. Kanunova O. N. Rzhevskaya A. G. Balkarov Kh. G. Alidzhanova |
| author_sort | M. Sh. Khubutiya |
| collection | DOAJ |
| description | Relevance: Arterial hypertension (HTN) in kidney transplant recipients is a major risk factor for cardiovascular diseases, graft rejection and premature death. In the post-transplant period in 80% of cases persistent or refractory arterial hypertension develops which is difficult to correct with conventional drug therapy. Treatment difficulties include the ineffectiveness of many first-line drugs and the fact that the most common immunosuppressive drugs (cyclosporine, tacrolimus and methylprednisolone) contribute to the development of hypertension. This type of hypertension represents a significant problem in clinical practice due to the complexity of treatment and high mortality. The need to study the treatment of post-transplant hypertension is due not only to its clinical significance, but also to the potential opportunity to improve treatment results and life expectancy of kidney transplant recipients.Objective: to study the genesis, risk factors, pathophysiology, diagnosis and treatment of posttransplant hypertension.Materials and methods: 37 literary sources were analyzed.Conclusions: High blood pressure exposes the recipient of a kidney transplant to the risk of CVD and mortality as well as increased systemic hypertension which can be a cause and a consequence of renal pathology. Hypertension is a modifiable risk factor contributing to the progression of renal failure. There is no any single treatment algorithm. It is often necessary to use several antihypertensive drugs to achieve the target blood pressure. |
| format | Article |
| id | doaj-art-1b9eb0c7dbea44d691dd102b2e0c2162 |
| institution | Kabale University |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2024-06-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-1b9eb0c7dbea44d691dd102b2e0c21622025-08-20T03:58:59ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792024-06-0114214014910.20340/vmi-rvz.2024.2.TX.2585Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatmentM. Sh. Khubutiya0F. M. Musaeva1T. A. Kanunova2O. N. Rzhevskaya3A. G. Balkarov4Kh. G. Alidzhanova5N.V. Sklifosovsky Research Institute of Emergency Medicine; Russian University of MedicineN.V. Sklifosovsky Research Institute of Emergency MedicineN.V. Sklifosovsky Research Institute of Emergency MedicineN.V. Sklifosovsky Research Institute of Emergency Medicine; Russian University of MedicineN.V. Sklifosovsky Research Institute of Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Research Institute of Health Organization and medical managementN.V. Sklifosovsky Research Institute of Emergency MedicineRelevance: Arterial hypertension (HTN) in kidney transplant recipients is a major risk factor for cardiovascular diseases, graft rejection and premature death. In the post-transplant period in 80% of cases persistent or refractory arterial hypertension develops which is difficult to correct with conventional drug therapy. Treatment difficulties include the ineffectiveness of many first-line drugs and the fact that the most common immunosuppressive drugs (cyclosporine, tacrolimus and methylprednisolone) contribute to the development of hypertension. This type of hypertension represents a significant problem in clinical practice due to the complexity of treatment and high mortality. The need to study the treatment of post-transplant hypertension is due not only to its clinical significance, but also to the potential opportunity to improve treatment results and life expectancy of kidney transplant recipients.Objective: to study the genesis, risk factors, pathophysiology, diagnosis and treatment of posttransplant hypertension.Materials and methods: 37 literary sources were analyzed.Conclusions: High blood pressure exposes the recipient of a kidney transplant to the risk of CVD and mortality as well as increased systemic hypertension which can be a cause and a consequence of renal pathology. Hypertension is a modifiable risk factor contributing to the progression of renal failure. There is no any single treatment algorithm. It is often necessary to use several antihypertensive drugs to achieve the target blood pressure.https://vestnik.reaviz.ru/jour/article/view/981kidney transplantationposttransplantation arterial hypertensionimmunosuppressive drugsantihypertensive drug |
| spellingShingle | M. Sh. Khubutiya F. M. Musaeva T. A. Kanunova O. N. Rzhevskaya A. G. Balkarov Kh. G. Alidzhanova Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье kidney transplantation posttransplantation arterial hypertension immunosuppressive drugs antihypertensive drug |
| title | Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment |
| title_full | Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment |
| title_fullStr | Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment |
| title_full_unstemmed | Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment |
| title_short | Arterial hypertension in kidney transplant recipients: pathophysiology, diagnostics, treatment |
| title_sort | arterial hypertension in kidney transplant recipients pathophysiology diagnostics treatment |
| topic | kidney transplantation posttransplantation arterial hypertension immunosuppressive drugs antihypertensive drug |
| url | https://vestnik.reaviz.ru/jour/article/view/981 |
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