Metastasis in renal cell carcinoma: Biology and implications for therapy
Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | Asian Journal of Urology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388216300509 |
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| _version_ | 1849727294934876160 |
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| author | Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan Sumanta K. Pal |
| author_facet | Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan Sumanta K. Pal |
| author_sort | Jun Gong |
| collection | DOAJ |
| description | Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through adjuvant therapy. Finally, we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis. Keywords: Renal cell carcinoma, Metastasis, Vascular endothelial growth factor, Mammalian target of rapamycin, Hypoxia inducible factor |
| format | Article |
| id | doaj-art-1b9de60cc4d7436eb160b39e45fd6725 |
| institution | DOAJ |
| issn | 2214-3882 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-1b9de60cc4d7436eb160b39e45fd67252025-08-20T03:09:54ZengElsevierAsian Journal of Urology2214-38822016-10-013428629210.1016/j.ajur.2016.08.006Metastasis in renal cell carcinoma: Biology and implications for therapyJun Gong0Manuel Caitano Maia1Nazli Dizman2Ameish Govindarajan3Sumanta K. Pal4Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USADivision of Medical Oncology, Instituto Hemomed de Oncologia e Hematologia. Av. Arnolfo de Azevedo, 121 - Cerqueira César - CEP 01248-040, Sao Paulo, BrazilDepartment of Internal Medicine, Istanbul Medeniyet University Goztepe Research and Training Hospital, Istanbul, TurkeyDepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USADepartment of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA; Corresponding author.Although multiple advances have been made in systemic therapy for renal cell carcinoma (RCC), metastatic RCC remains incurable. In the current review, we focus on the underlying biology of RCC and plausible mechanisms of metastasis. We further outline evolving strategies to combat metastasis through adjuvant therapy. Finally, we discuss clinical patterns of metastasis in RCC and how distinct systemic therapy approaches may be considered based on the anatomic location of metastasis. Keywords: Renal cell carcinoma, Metastasis, Vascular endothelial growth factor, Mammalian target of rapamycin, Hypoxia inducible factorhttp://www.sciencedirect.com/science/article/pii/S2214388216300509 |
| spellingShingle | Jun Gong Manuel Caitano Maia Nazli Dizman Ameish Govindarajan Sumanta K. Pal Metastasis in renal cell carcinoma: Biology and implications for therapy Asian Journal of Urology |
| title | Metastasis in renal cell carcinoma: Biology and implications for therapy |
| title_full | Metastasis in renal cell carcinoma: Biology and implications for therapy |
| title_fullStr | Metastasis in renal cell carcinoma: Biology and implications for therapy |
| title_full_unstemmed | Metastasis in renal cell carcinoma: Biology and implications for therapy |
| title_short | Metastasis in renal cell carcinoma: Biology and implications for therapy |
| title_sort | metastasis in renal cell carcinoma biology and implications for therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2214388216300509 |
| work_keys_str_mv | AT jungong metastasisinrenalcellcarcinomabiologyandimplicationsfortherapy AT manuelcaitanomaia metastasisinrenalcellcarcinomabiologyandimplicationsfortherapy AT nazlidizman metastasisinrenalcellcarcinomabiologyandimplicationsfortherapy AT ameishgovindarajan metastasisinrenalcellcarcinomabiologyandimplicationsfortherapy AT sumantakpal metastasisinrenalcellcarcinomabiologyandimplicationsfortherapy |