Advances in the study of exosomes in cardiovascular diseases
Background: Cardiovascular disease (CVD) has been the leading cause of death worldwide for many years. In recent years, exosomes have gained extensive attention in the cardiovascular system due to their excellent biocompatibility. Studies have extensively researched miRNAs in exosomes and found that...
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| Format: | Article |
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Elsevier
2024-12-01
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| Series: | Journal of Advanced Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123223004022 |
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| author | Zhaobo Zhang Yuanming Zou Chunyu Song Kexin Cao Kexin Cai Shuxian Chen Yanjiao Wu Danxi Geng Guozhe Sun Naijin Zhang Xingang Zhang Yixiao Zhang Yingxian Sun Ying Zhang |
| author_facet | Zhaobo Zhang Yuanming Zou Chunyu Song Kexin Cao Kexin Cai Shuxian Chen Yanjiao Wu Danxi Geng Guozhe Sun Naijin Zhang Xingang Zhang Yixiao Zhang Yingxian Sun Ying Zhang |
| author_sort | Zhaobo Zhang |
| collection | DOAJ |
| description | Background: Cardiovascular disease (CVD) has been the leading cause of death worldwide for many years. In recent years, exosomes have gained extensive attention in the cardiovascular system due to their excellent biocompatibility. Studies have extensively researched miRNAs in exosomes and found that they play critical roles in various physiological and pathological processes in the cardiovascular system. These processes include promoting or inhibiting inflammatory responses, promoting angiogenesis, participating in cell proliferation and migration, and promoting pathological progression such as fibrosis. Aim of review: This systematic review examines the role of exosomes in various cardiovascular diseases such as atherosclerosis, myocardial infarction, ischemia–reperfusion injury, heart failure and cardiomyopathy. It also presents the latest treatment and prevention methods utilizing exosomes. The study aims to provide new insights and approaches for preventing and treating cardiovascular diseases by exploring the relationship between exosomes and these conditions. Furthermore, the review emphasizes the potential clinical use of exosomes as biomarkers for diagnosing cardiovascular diseases. Key scientific concepts of review: Exosomes are nanoscale vesicles surrounded by lipid bilayers that are secreted by most cells in the body. They are heterogeneous, varying in size and composition, with a diameter typically ranging from 40 to 160 nm. Exosomes serve as a means of information communication between cells, carrying various biologically active substances, including lipids, proteins, and small RNAs such as miRNAs and lncRNAs. As a result, they participate in both physiological and pathological processes within the body. |
| format | Article |
| id | doaj-art-1b97be7fd73b4568b02843e21e4b9270 |
| institution | OA Journals |
| issn | 2090-1232 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj-art-1b97be7fd73b4568b02843e21e4b92702025-08-20T02:37:29ZengElsevierJournal of Advanced Research2090-12322024-12-016613315310.1016/j.jare.2023.12.014Advances in the study of exosomes in cardiovascular diseasesZhaobo Zhang0Yuanming Zou1Chunyu Song2Kexin Cao3Kexin Cai4Shuxian Chen5Yanjiao Wu6Danxi Geng7Guozhe Sun8Naijin Zhang9Xingang Zhang10Yixiao Zhang11Yingxian Sun12Ying Zhang13Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of ChinaDepartment of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China; Corresponding authors.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China; Institute of Health Sciences, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, 110122, Liaoning Province, People's Republic of China; Key Laboratory of Reproductive and Genetic Medicine, China Medical University, National Health Commission, 77 Puhe Road, Shenbei New District, Shenyang, 110122, Liaoning Province, People's Republic of China; Corresponding authors.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China; Corresponding authors.Department of Urology Surgery, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning Province, People's Republic of China; Corresponding authors.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China; Institute of Health Sciences, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, 110122, Liaoning Province, People's Republic of China; Corresponding authors.Department of Cardiology, The First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China; Institute of Health Sciences, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, 110122, Liaoning Province, People's Republic of China; Corresponding authors.Background: Cardiovascular disease (CVD) has been the leading cause of death worldwide for many years. In recent years, exosomes have gained extensive attention in the cardiovascular system due to their excellent biocompatibility. Studies have extensively researched miRNAs in exosomes and found that they play critical roles in various physiological and pathological processes in the cardiovascular system. These processes include promoting or inhibiting inflammatory responses, promoting angiogenesis, participating in cell proliferation and migration, and promoting pathological progression such as fibrosis. Aim of review: This systematic review examines the role of exosomes in various cardiovascular diseases such as atherosclerosis, myocardial infarction, ischemia–reperfusion injury, heart failure and cardiomyopathy. It also presents the latest treatment and prevention methods utilizing exosomes. The study aims to provide new insights and approaches for preventing and treating cardiovascular diseases by exploring the relationship between exosomes and these conditions. Furthermore, the review emphasizes the potential clinical use of exosomes as biomarkers for diagnosing cardiovascular diseases. Key scientific concepts of review: Exosomes are nanoscale vesicles surrounded by lipid bilayers that are secreted by most cells in the body. They are heterogeneous, varying in size and composition, with a diameter typically ranging from 40 to 160 nm. Exosomes serve as a means of information communication between cells, carrying various biologically active substances, including lipids, proteins, and small RNAs such as miRNAs and lncRNAs. As a result, they participate in both physiological and pathological processes within the body.http://www.sciencedirect.com/science/article/pii/S2090123223004022 |
| spellingShingle | Zhaobo Zhang Yuanming Zou Chunyu Song Kexin Cao Kexin Cai Shuxian Chen Yanjiao Wu Danxi Geng Guozhe Sun Naijin Zhang Xingang Zhang Yixiao Zhang Yingxian Sun Ying Zhang Advances in the study of exosomes in cardiovascular diseases Journal of Advanced Research |
| title | Advances in the study of exosomes in cardiovascular diseases |
| title_full | Advances in the study of exosomes in cardiovascular diseases |
| title_fullStr | Advances in the study of exosomes in cardiovascular diseases |
| title_full_unstemmed | Advances in the study of exosomes in cardiovascular diseases |
| title_short | Advances in the study of exosomes in cardiovascular diseases |
| title_sort | advances in the study of exosomes in cardiovascular diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2090123223004022 |
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