Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review
Background/Objectives: Cerebral amyloid angiopathy (CAA) is one of the most prevalent small vessel diseases (SVDs). Its diagnostic criteria rely mainly on neuroimaging markers, in particular using Magnetic Resonance Imaging (MRI), as pathology-based diagnoses are only occasionally available. Amyloid...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/7/3973 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850213198298349568 |
|---|---|
| author | Marialuisa Zedde Fabrizio Piazza Rosario Pascarella |
| author_facet | Marialuisa Zedde Fabrizio Piazza Rosario Pascarella |
| author_sort | Marialuisa Zedde |
| collection | DOAJ |
| description | Background/Objectives: Cerebral amyloid angiopathy (CAA) is one of the most prevalent small vessel diseases (SVDs). Its diagnostic criteria rely mainly on neuroimaging markers, in particular using Magnetic Resonance Imaging (MRI), as pathology-based diagnoses are only occasionally available. Amyloid PET is frequently used to assess parenchymal amyloid deposition in Alzheimer’s disease (AD), but amyloid tracers are not specific to vascular and parenchymal amyloids. The aim of this scoping review is to assess the usefulness of amyloid PET imaging in CAA. Methods: A systematic literature search was performed, aiming to assess amyloid PET performance in the following situations: (I) CAA-related intracerebral hemorrhage (ICH) and convexal subarachnoid hemorrhage; (II) pathology-proven CAA; (III) CAA-related inflammation; (IV) hereditary CAA. Results: A total of 52 studies were retrieved, including three systematic reviews, and from these, a specific selection was taken according to each objective, confirming the diagnostic value of amyloid PET added to MRI and clinical information in all the selected situations, although with some limitations. Conclusions: Amyloid PET reliably detects increased global and region-specific amyloid deposition in CAA patients, with a characteristic occipital-predominant pattern. Continued advancements in tracer development and imaging methodologies are needed to increase specificity. |
| format | Article |
| id | doaj-art-1b8e31f040a64f67873fa65880fba6f7 |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-1b8e31f040a64f67873fa65880fba6f72025-08-20T02:09:11ZengMDPI AGApplied Sciences2076-34172025-04-01157397310.3390/app15073973Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping ReviewMarialuisa Zedde0Fabrizio Piazza1Rosario Pascarella2Neurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, ItalyCAA and AD Translational Research and Biomarkers Laboratory, School of Medicine, University of Milano-Bicocca, 20900 Monza, ItalyCAA and AD Translational Research and Biomarkers Laboratory, School of Medicine, University of Milano-Bicocca, 20900 Monza, ItalyBackground/Objectives: Cerebral amyloid angiopathy (CAA) is one of the most prevalent small vessel diseases (SVDs). Its diagnostic criteria rely mainly on neuroimaging markers, in particular using Magnetic Resonance Imaging (MRI), as pathology-based diagnoses are only occasionally available. Amyloid PET is frequently used to assess parenchymal amyloid deposition in Alzheimer’s disease (AD), but amyloid tracers are not specific to vascular and parenchymal amyloids. The aim of this scoping review is to assess the usefulness of amyloid PET imaging in CAA. Methods: A systematic literature search was performed, aiming to assess amyloid PET performance in the following situations: (I) CAA-related intracerebral hemorrhage (ICH) and convexal subarachnoid hemorrhage; (II) pathology-proven CAA; (III) CAA-related inflammation; (IV) hereditary CAA. Results: A total of 52 studies were retrieved, including three systematic reviews, and from these, a specific selection was taken according to each objective, confirming the diagnostic value of amyloid PET added to MRI and clinical information in all the selected situations, although with some limitations. Conclusions: Amyloid PET reliably detects increased global and region-specific amyloid deposition in CAA patients, with a characteristic occipital-predominant pattern. Continued advancements in tracer development and imaging methodologies are needed to increase specificity.https://www.mdpi.com/2076-3417/15/7/3973cerebral amyloid angiopathyCAAamyloid PETMRIcortical superficial siderosismicrobleeds |
| spellingShingle | Marialuisa Zedde Fabrizio Piazza Rosario Pascarella Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review Applied Sciences cerebral amyloid angiopathy CAA amyloid PET MRI cortical superficial siderosis microbleeds |
| title | Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review |
| title_full | Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review |
| title_fullStr | Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review |
| title_full_unstemmed | Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review |
| title_short | Positron Emission Tomography in Cerebral Amyloid Angiopathy: A Scoping Review |
| title_sort | positron emission tomography in cerebral amyloid angiopathy a scoping review |
| topic | cerebral amyloid angiopathy CAA amyloid PET MRI cortical superficial siderosis microbleeds |
| url | https://www.mdpi.com/2076-3417/15/7/3973 |
| work_keys_str_mv | AT marialuisazedde positronemissiontomographyincerebralamyloidangiopathyascopingreview AT fabriziopiazza positronemissiontomographyincerebralamyloidangiopathyascopingreview AT rosariopascarella positronemissiontomographyincerebralamyloidangiopathyascopingreview |