Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae

Abstract Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections w...

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Main Authors: Adriana Cabrera, Emily Mason, Liam P. Mullins, Manish Sadarangani
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-025-00100-8
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author Adriana Cabrera
Emily Mason
Liam P. Mullins
Manish Sadarangani
author_facet Adriana Cabrera
Emily Mason
Liam P. Mullins
Manish Sadarangani
author_sort Adriana Cabrera
collection DOAJ
description Abstract Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic E. coli and K. pneumoniae by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.
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series npj Antimicrobials and Resistance
spelling doaj-art-1b8a97083ec44de3a97f6292dff51cbc2025-08-20T01:47:32ZengNature Portfolionpj Antimicrobials and Resistance2731-87452025-04-013111410.1038/s44259-025-00100-8Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniaeAdriana Cabrera0Emily Mason1Liam P. Mullins2Manish Sadarangani3Experimental Medicine Program, Department of Medicine, University of British ColumbiaExperimental Medicine Program, Department of Medicine, University of British ColumbiaExperimental Medicine Program, Department of Medicine, University of British ColumbiaVaccine Evaluation Center, BC Children’s Hospital Research InstituteAbstract Antimicrobial-resistant Enterobacteriaceae are increasingly a clinical challenge. In particular, extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae threaten public health. Vaccination presents a long-term strategy to reduce both drug-susceptible and resistant infections while maintaining current clinical therapies. The review aims to emphasize the need for vaccines targeting extraintestinal pathogenic E. coli and K. pneumoniae by providing an overview of disease burden, antimicrobial resistance, therapeutics, and vaccine development.https://doi.org/10.1038/s44259-025-00100-8
spellingShingle Adriana Cabrera
Emily Mason
Liam P. Mullins
Manish Sadarangani
Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
npj Antimicrobials and Resistance
title Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
title_full Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
title_fullStr Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
title_full_unstemmed Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
title_short Antimicrobial resistance and vaccines in Enterobacteriaceae including extraintestinal pathogenic Escherichia coli and Klebsiella pneumoniae
title_sort antimicrobial resistance and vaccines in enterobacteriaceae including extraintestinal pathogenic escherichia coli and klebsiella pneumoniae
url https://doi.org/10.1038/s44259-025-00100-8
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