Cooperative Role of Carbonic Anhydrase IX/XII in Driving Tumor Invasion and Metastasis: A Novel Targeted Therapeutic Strategy

Cooperative Role of Carbonic Anhydrase IX/XII in Driving Tumor Invasion and Metastasis: A Novel Targeted Therapeutic Strategy

Cancer invasion and metastasis are critical factors that influence patient prognosis. Carbonic anhydrase IX (CA IX) and carbonic anhydrase XII (CA XII) are key regulators of hypoxia and pH homeostasis in the tumor microenvironment (TME). It has been verified that both CA IX and CA XII play significa...

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Bibliographic Details
Main Authors: Hanyu Yang, Rui Chen, Xiang Zheng, Yufan Luo, Mingxuan Yao, Famin Ke, Xiurong Guo, Xiaoyan Liu, Qiuyu Liu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
carbonic anhydrase IX (CA IX)
carbonic anhydrase XII (CA XII)
invasion
tumor metastasis
therapy
Online Access:https://www.mdpi.com/2073-4409/14/10/693
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