Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases

Aim. In this work, we set out to assess the specific features of vascular endothelium in patients suffering from severe (pan-ulcerative) and complicated forms of ulcerative colitis (UC) and Crohn’s disease (CD).Materials and methods. The research sample consisted in 65 patients with UC (n = 45) and...

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Main Authors: O. V. Khlynova, E. A. Stepina
Format: Article
Language:Russian
Published: Gastro LLC 2018-11-01
Series:Российский журнал гастроэнтерологии, гепатологии, колопроктологии
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Online Access:https://www.gastro-j.ru/jour/article/view/265
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author O. V. Khlynova
E. A. Stepina
author_facet O. V. Khlynova
E. A. Stepina
author_sort O. V. Khlynova
collection DOAJ
description Aim. In this work, we set out to assess the specific features of vascular endothelium in patients suffering from severe (pan-ulcerative) and complicated forms of ulcerative colitis (UC) and Crohn’s disease (CD).Materials and methods. The research sample consisted in 65 patients with UC (n = 45) and CD (n = 20), who were either in the acute phase or had been diagnosed with such conditions for the first time. For assessing endothelial dysfunction (ED), we used such markers as levels of vascular endothelial growth factor (VEGF) in the blood serum and the number of plasma desquamated endotheliocytes (DEC).Results. The indicators of vascular endothelial dysfunction are shown to be significantly higher in patients with severe, pan-ulcerative forms of inflammatory bowel diseases (IBD). A statistically significant relationship has been established between ED indicators and the severity and localisation of the pathological process, the extra-intestinal manifestations and complications of the disease. A dependence of the endothelial dysfunction indicators on the UC endoscopic activity has been determined. A positive correlation between the levels of VEGF and DEC and the markers of systemic inflammation (ESR, CRP and fibrinogen) has been revealed.Conclusion. It is determined that, in IBD patients, endothelium dysfunction is manifested in an increase in the VEGF and DEC levels. The indicators of endothelial dysfunction are shown to be directly correlated with the serum markers of systemic inflammation. Therefore, VEGF and DEC values can be used not only as criteria for assessing the intensity of IBD, but also as predictors of a complicated disease course.
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spelling doaj-art-1b87872350554d7aa0257e02993c3a2d2025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-11-012859810410.22416/1382-4376-2018-28-5-98-104264Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel DiseasesO. V. Khlynova0E. A. Stepina1Wagner Perm State Medical University.Wagner Perm State Medical University.Aim. In this work, we set out to assess the specific features of vascular endothelium in patients suffering from severe (pan-ulcerative) and complicated forms of ulcerative colitis (UC) and Crohn’s disease (CD).Materials and methods. The research sample consisted in 65 patients with UC (n = 45) and CD (n = 20), who were either in the acute phase or had been diagnosed with such conditions for the first time. For assessing endothelial dysfunction (ED), we used such markers as levels of vascular endothelial growth factor (VEGF) in the blood serum and the number of plasma desquamated endotheliocytes (DEC).Results. The indicators of vascular endothelial dysfunction are shown to be significantly higher in patients with severe, pan-ulcerative forms of inflammatory bowel diseases (IBD). A statistically significant relationship has been established between ED indicators and the severity and localisation of the pathological process, the extra-intestinal manifestations and complications of the disease. A dependence of the endothelial dysfunction indicators on the UC endoscopic activity has been determined. A positive correlation between the levels of VEGF and DEC and the markers of systemic inflammation (ESR, CRP and fibrinogen) has been revealed.Conclusion. It is determined that, in IBD patients, endothelium dysfunction is manifested in an increase in the VEGF and DEC levels. The indicators of endothelial dysfunction are shown to be directly correlated with the serum markers of systemic inflammation. Therefore, VEGF and DEC values can be used not only as criteria for assessing the intensity of IBD, but also as predictors of a complicated disease course.https://www.gastro-j.ru/jour/article/view/265endothelial dysfunctionulcerative colitiscrohn’s diseasevascular endothelial growth factordesquamated endotheliocytes
spellingShingle O. V. Khlynova
E. A. Stepina
Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
Российский журнал гастроэнтерологии, гепатологии, колопроктологии
endothelial dysfunction
ulcerative colitis
crohn’s disease
vascular endothelial growth factor
desquamated endotheliocytes
title Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
title_full Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
title_fullStr Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
title_full_unstemmed Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
title_short Specific Features of Vascular Endothelium in Patients with Severe Forms of Inflammatory Bowel Diseases
title_sort specific features of vascular endothelium in patients with severe forms of inflammatory bowel diseases
topic endothelial dysfunction
ulcerative colitis
crohn’s disease
vascular endothelial growth factor
desquamated endotheliocytes
url https://www.gastro-j.ru/jour/article/view/265
work_keys_str_mv AT ovkhlynova specificfeaturesofvascularendotheliuminpatientswithsevereformsofinflammatoryboweldiseases
AT eastepina specificfeaturesofvascularendotheliuminpatientswithsevereformsofinflammatoryboweldiseases