Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale
Our objective was to develop a working definition of nonresponse to analgesic treatment of arthritis, focusing on the measurement of pain on the 0–100 mm pain visual analog scale (VAS). We reviewed the literature to assess the smallest detectable difference (SDD), the minimal detectable change (MDC)...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2011/231926 |
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| author | Melissa E. Stauffer Stephanie D. Taylor Douglas J. Watson Paul M. Peloso Alan Morrison |
| author_facet | Melissa E. Stauffer Stephanie D. Taylor Douglas J. Watson Paul M. Peloso Alan Morrison |
| author_sort | Melissa E. Stauffer |
| collection | DOAJ |
| description | Our objective was to develop a working definition of nonresponse to analgesic treatment of arthritis, focusing on the measurement of pain on the 0–100 mm pain visual analog scale (VAS). We reviewed the literature to assess the smallest detectable difference (SDD), the minimal detectable change (MDC), and the minimal clinically important difference (MCID). The SDD for improvement reported in three studies of rheumatoid arthritis was 18.6, 19.0, and 20.0. The median MDC was 25.4 for 7 studies of osteoarthritis and 5 studies of rheumatoid arthritis (calculated for a reliability coefficient of 0.85). The MCID increased with increasing baseline pain score. For baseline VAS tertiles defined by scores of 30–49, 50–65, and >65, the MCID for improvement was, respectively, 7–11 units, 19–27 units, and 29–37 units. Nonresponse can thus be defined in terms of the MDC for low baseline pain scores and in terms of the MCID for high baseline scores. |
| format | Article |
| id | doaj-art-1b85d4c0ee3142b48503a1442c74dcc9 |
| institution | Kabale University |
| issn | 2042-0099 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-1b85d4c0ee3142b48503a1442c74dcc92025-02-03T01:03:27ZengWileyInternational Journal of Inflammation2042-00992011-01-01201110.4061/2011/231926231926Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog ScaleMelissa E. Stauffer0Stephanie D. Taylor1Douglas J. Watson2Paul M. Peloso3Alan Morrison4Scribco Pharmaceutical Writing, P.O. Box 1525, Blue Bell, PA 19422, USADepartments of Global Health Outcomes, Epidemiology, and Clinical Development, Merck & Co., Inc., One Merck Drive, Whitehouse Station, NJ 08889, USADepartments of Global Health Outcomes, Epidemiology, and Clinical Development, Merck & Co., Inc., One Merck Drive, Whitehouse Station, NJ 08889, USADepartments of Global Health Outcomes, Epidemiology, and Clinical Development, Merck & Co., Inc., One Merck Drive, Whitehouse Station, NJ 08889, USAScribco Pharmaceutical Writing, P.O. Box 1525, Blue Bell, PA 19422, USAOur objective was to develop a working definition of nonresponse to analgesic treatment of arthritis, focusing on the measurement of pain on the 0–100 mm pain visual analog scale (VAS). We reviewed the literature to assess the smallest detectable difference (SDD), the minimal detectable change (MDC), and the minimal clinically important difference (MCID). The SDD for improvement reported in three studies of rheumatoid arthritis was 18.6, 19.0, and 20.0. The median MDC was 25.4 for 7 studies of osteoarthritis and 5 studies of rheumatoid arthritis (calculated for a reliability coefficient of 0.85). The MCID increased with increasing baseline pain score. For baseline VAS tertiles defined by scores of 30–49, 50–65, and >65, the MCID for improvement was, respectively, 7–11 units, 19–27 units, and 29–37 units. Nonresponse can thus be defined in terms of the MDC for low baseline pain scores and in terms of the MCID for high baseline scores.http://dx.doi.org/10.4061/2011/231926 |
| spellingShingle | Melissa E. Stauffer Stephanie D. Taylor Douglas J. Watson Paul M. Peloso Alan Morrison Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale International Journal of Inflammation |
| title | Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale |
| title_full | Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale |
| title_fullStr | Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale |
| title_full_unstemmed | Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale |
| title_short | Definition of Nonresponse to Analgesic Treatment of Arthritic Pain: An Analytical Literature Review of the Smallest Detectable Difference, the Minimal Detectable Change, and the Minimal Clinically Important Difference on the Pain Visual Analog Scale |
| title_sort | definition of nonresponse to analgesic treatment of arthritic pain an analytical literature review of the smallest detectable difference the minimal detectable change and the minimal clinically important difference on the pain visual analog scale |
| url | http://dx.doi.org/10.4061/2011/231926 |
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