Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry.

Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry.

We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT in...

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Main Authors: Lalita Priyamvada, Wouter W Kallemeijn, Monica Faronato, Kimberly Wilkins, Cynthia S Goldsmith, Catherine A Cotter, Suany Ojeda, Roberto Solari, Bernard Moss, Edward W Tate, Panayampalli Subbian Satheshkumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010662&type=printable
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