Meningococcal B Vaccination (4CMenB) in Infants and Toddlers
Neisseria meningitidis is a Gram-negative pathogen that actively invades its human host and leads to the development of life-threatening pathologies. One of the leading causes of death in the world, N. meningitidis can be responsible for nearly 1,000 new infections per 100,000 subjects during an epi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/402381 |
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| author | Susanna Esposito Claudia Tagliabue Samantha Bosis |
| author_facet | Susanna Esposito Claudia Tagliabue Samantha Bosis |
| author_sort | Susanna Esposito |
| collection | DOAJ |
| description | Neisseria meningitidis is a Gram-negative pathogen that actively invades its human host and leads to the development of life-threatening pathologies. One of the leading causes of death in the world, N. meningitidis can be responsible for nearly 1,000 new infections per 100,000 subjects during an epidemic period. The bacterial species are classified into 12 serogroups, five of which (A, B, C, W, and Y) cause the majority of meningitides. The three purified protein conjugate vaccines currently available target serogroups A, C, W, and Y. Serogroup B has long been a challenge but the discovery of the complete genome sequence of an MenB strain has allowed the development of a specific four-component vaccine (4CMenB). This review describes the pathogenetic role of N. meningitidis and the recent literature concerning the new meningococcal vaccine. |
| format | Article |
| id | doaj-art-1b7ee71947f04c0a9517bdb0b8f98d79 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-1b7ee71947f04c0a9517bdb0b8f98d792025-02-03T01:28:44ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/402381402381Meningococcal B Vaccination (4CMenB) in Infants and ToddlersSusanna Esposito0Claudia Tagliabue1Samantha Bosis2Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyPediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyNeisseria meningitidis is a Gram-negative pathogen that actively invades its human host and leads to the development of life-threatening pathologies. One of the leading causes of death in the world, N. meningitidis can be responsible for nearly 1,000 new infections per 100,000 subjects during an epidemic period. The bacterial species are classified into 12 serogroups, five of which (A, B, C, W, and Y) cause the majority of meningitides. The three purified protein conjugate vaccines currently available target serogroups A, C, W, and Y. Serogroup B has long been a challenge but the discovery of the complete genome sequence of an MenB strain has allowed the development of a specific four-component vaccine (4CMenB). This review describes the pathogenetic role of N. meningitidis and the recent literature concerning the new meningococcal vaccine.http://dx.doi.org/10.1155/2015/402381 |
| spellingShingle | Susanna Esposito Claudia Tagliabue Samantha Bosis Meningococcal B Vaccination (4CMenB) in Infants and Toddlers Journal of Immunology Research |
| title | Meningococcal B Vaccination (4CMenB) in Infants and Toddlers |
| title_full | Meningococcal B Vaccination (4CMenB) in Infants and Toddlers |
| title_fullStr | Meningococcal B Vaccination (4CMenB) in Infants and Toddlers |
| title_full_unstemmed | Meningococcal B Vaccination (4CMenB) in Infants and Toddlers |
| title_short | Meningococcal B Vaccination (4CMenB) in Infants and Toddlers |
| title_sort | meningococcal b vaccination 4cmenb in infants and toddlers |
| url | http://dx.doi.org/10.1155/2015/402381 |
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