Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience

Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK...

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Main Authors: Ajay Patel, Homan Mohammadi, Tuo Dong, Kevin Ren-Yeh Shiue, Douglas Frye, Yi Le, Shaheryar Ansari, Gordon A Watson, James C Miller, Tim Lautenschlaeger
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:CNS Oncology
Subjects:
Online Access:https://www.futuremedicine.com/doi/10.2217/cns-2017-0029
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author Ajay Patel
Homan Mohammadi
Tuo Dong
Kevin Ren-Yeh Shiue
Douglas Frye
Yi Le
Shaheryar Ansari
Gordon A Watson
James C Miller
Tim Lautenschlaeger
author_facet Ajay Patel
Homan Mohammadi
Tuo Dong
Kevin Ren-Yeh Shiue
Douglas Frye
Yi Le
Shaheryar Ansari
Gordon A Watson
James C Miller
Tim Lautenschlaeger
author_sort Ajay Patel
collection DOAJ
description Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01–2.0 cc). Median prescribed dose was 17.5 Gy to the 50% isodose line (range: 14–22 Gy). Median survival after GK SRS treatment to brainstem lesion was 17.2 months (range: 2.8–45.6 months). The experience at Indiana University confirms the safety and efficacy of range of GK SRS prescription doses (14–22 Gy) to brainstem metastases.
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id doaj-art-1b6eab55b47e4d83adf30644541f9fcf
institution OA Journals
issn 2045-0907
2045-0915
language English
publishDate 2018-01-01
publisher Taylor & Francis Group
record_format Article
series CNS Oncology
spelling doaj-art-1b6eab55b47e4d83adf30644541f9fcf2025-08-20T02:26:02ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152018-01-0171152310.2217/cns-2017-0029Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experienceAjay Patel0Homan Mohammadi1Tuo Dong2Kevin Ren-Yeh Shiue3Douglas Frye4Yi Le5Shaheryar Ansari6Gordon A Watson7James C Miller8Tim Lautenschlaeger91Indiana University School of Medicine, Indianapolis, IN 46202, USA1Indiana University School of Medicine, Indianapolis, IN 46202, USA1Indiana University School of Medicine, Indianapolis, IN 46202, USA1Indiana University School of Medicine, Indianapolis, IN 46202, USA2Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA2Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA1Indiana University School of Medicine, Indianapolis, IN 46202, USA2Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA3Goodman Campbell Brain & Spine & Department of Neurological Surgery, Indiana University, Indianapolis, IN 46202, USA2Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USABrainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01–2.0 cc). Median prescribed dose was 17.5 Gy to the 50% isodose line (range: 14–22 Gy). Median survival after GK SRS treatment to brainstem lesion was 17.2 months (range: 2.8–45.6 months). The experience at Indiana University confirms the safety and efficacy of range of GK SRS prescription doses (14–22 Gy) to brainstem metastases.https://www.futuremedicine.com/doi/10.2217/cns-2017-0029brainstemGamma Knifemetastasisradiosurgery
spellingShingle Ajay Patel
Homan Mohammadi
Tuo Dong
Kevin Ren-Yeh Shiue
Douglas Frye
Yi Le
Shaheryar Ansari
Gordon A Watson
James C Miller
Tim Lautenschlaeger
Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
CNS Oncology
brainstem
Gamma Knife
metastasis
radiosurgery
title Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
title_full Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
title_fullStr Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
title_full_unstemmed Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
title_short Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience
title_sort brainstem metastases treated with gamma knife stereotactic radiosurgery the indiana university health experience
topic brainstem
Gamma Knife
metastasis
radiosurgery
url https://www.futuremedicine.com/doi/10.2217/cns-2017-0029
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