Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration
Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin’s lymp...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/658745 |
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| author | Nobuo Takemori Hiroyuki Kaneko Masaya Nakamura Masaru Kojima |
| author_facet | Nobuo Takemori Hiroyuki Kaneko Masaya Nakamura Masaru Kojima |
| author_sort | Nobuo Takemori |
| collection | DOAJ |
| description | Patients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin’s lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission. |
| format | Article |
| id | doaj-art-1b6b3f1a66ab4ec897bf8e0eab3a0e38 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-1b6b3f1a66ab4ec897bf8e0eab3a0e382025-02-03T01:32:52ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/658745658745Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin AdministrationNobuo Takemori0Hiroyuki Kaneko1Masaya Nakamura2Masaru Kojima3Division of Hematology, Department of Internal Medicine, Imai Hospital, Tanaka-cho 100, Ashikaga, Tochigi 326-0822, JapanDepartment of Orthopedics, Imai Hospital, Tanaka-cho 100, Ashikaga, Tochigi 326-0822, JapanDepartment of Surgery, Imai Hospital, Tanaka-cho 100, Ashikaga, Tochigi 326-0822, JapanDepartment of Anatomic and Diagnostic Pathology, School of Medicine, Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, JapanPatients with rheumatoid arthritis (RA) are known to develop lymphoproliferative disorders (LPDs) during the course of illness, particularly in cases treated with methotrexate (MTX) for long periods. We describe a case of MTX-related Epstein-Barr-virus-(EBV-) associated LPD resembling Hodgkin’s lymphoma (HL), in which a dramatic complete remission was achieved after withdrawal of MTX coupled with clarithromycin (CAM) administration. Withdrawal of MTX coupled with CAM administration seemed to be effective for treating MTX-related EBV-associated LPDs. In particular, an immunomodulative effect of CAM might have been involved in achieving complete remission.http://dx.doi.org/10.1155/2012/658745 |
| spellingShingle | Nobuo Takemori Hiroyuki Kaneko Masaya Nakamura Masaru Kojima Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration Case Reports in Hematology |
| title | Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration |
| title_full | Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration |
| title_fullStr | Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration |
| title_full_unstemmed | Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration |
| title_short | Complete Remission of Methotrexate-Related Epstein-Barr-Virus-Associated Hodgkin-Like Lymphoma following Withdrawal of MTX Coupled with Clarithromycin Administration |
| title_sort | complete remission of methotrexate related epstein barr virus associated hodgkin like lymphoma following withdrawal of mtx coupled with clarithromycin administration |
| url | http://dx.doi.org/10.1155/2012/658745 |
| work_keys_str_mv | AT nobuotakemori completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration AT hiroyukikaneko completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration AT masayanakamura completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration AT masarukojima completeremissionofmethotrexaterelatedepsteinbarrvirusassociatedhodgkinlikelymphomafollowingwithdrawalofmtxcoupledwithclarithromycinadministration |