Improving Fat Graft Survival Using Soluble Molecule Preconditioning
Fat grafting is widely used in plastic surgery to correct soft tissue deformities. A major limitation of this technique is the poor long-term volume retention of the injected fat due to tissue remodeling and adipocyte death. To address this issue, various optimizations of the grafting process have b...
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| Format: | Article |
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/526 |
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| author | Nabil Amraoui Isabelle Xu Jorge Robles Cortés Chanel Beaudoin Cloutier Julie Fradette |
| author_facet | Nabil Amraoui Isabelle Xu Jorge Robles Cortés Chanel Beaudoin Cloutier Julie Fradette |
| author_sort | Nabil Amraoui |
| collection | DOAJ |
| description | Fat grafting is widely used in plastic surgery to correct soft tissue deformities. A major limitation of this technique is the poor long-term volume retention of the injected fat due to tissue remodeling and adipocyte death. To address this issue, various optimizations of the grafting process have been proposed. This scoping review focuses on preclinical and clinical studies that investigated the impact of various classes of soluble molecules on fat grafting outcomes. Globally, we describe that these molecules can be classified as acting through three main mechanisms to improve graft retention: supporting adipogenesis, improving vascularization, and reducing oxidative stress. A variety of 18 molecules are discussed, including insulin, VEGF, deferoxamine, botulinum toxin A, apocynin, N-acetylcysteine, and melatonin. Many biomolecules have shown the potential to improve long-term outcomes of fat grafts through enhanced cell survival and higher volume retention. However, the variability between experimental protocols, as well as the scarcity of clinical studies, remain obstacles to clinical translation. In order to determine the best preconditioning method for fat grafts, future studies should focus on dosage optimization, more sustained delivery of the molecules, and the design of homogenous experimental protocols and specific clinical trials. |
| format | Article |
| id | doaj-art-1b6861632bb440778140ece46d1d0dd1 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-1b6861632bb440778140ece46d1d0dd12025-08-20T02:17:20ZengMDPI AGBiomolecules2218-273X2025-04-0115452610.3390/biom15040526Improving Fat Graft Survival Using Soluble Molecule PreconditioningNabil Amraoui0Isabelle Xu1Jorge Robles Cortés2Chanel Beaudoin Cloutier3Julie Fradette4Regenerative Medicine Division, CHU de Quebec-Université Laval Research Center, Quebec, QC G1J 1Z4, CanadaDepartment of Surgery, Faculty of Medicine, Université Laval, Quebec, QC G1V 0A6, CanadaDepartment of Surgery, Faculty of Medicine, Université Laval, Quebec, QC G1V 0A6, CanadaRegenerative Medicine Division, CHU de Quebec-Université Laval Research Center, Quebec, QC G1J 1Z4, CanadaRegenerative Medicine Division, CHU de Quebec-Université Laval Research Center, Quebec, QC G1J 1Z4, CanadaFat grafting is widely used in plastic surgery to correct soft tissue deformities. A major limitation of this technique is the poor long-term volume retention of the injected fat due to tissue remodeling and adipocyte death. To address this issue, various optimizations of the grafting process have been proposed. This scoping review focuses on preclinical and clinical studies that investigated the impact of various classes of soluble molecules on fat grafting outcomes. Globally, we describe that these molecules can be classified as acting through three main mechanisms to improve graft retention: supporting adipogenesis, improving vascularization, and reducing oxidative stress. A variety of 18 molecules are discussed, including insulin, VEGF, deferoxamine, botulinum toxin A, apocynin, N-acetylcysteine, and melatonin. Many biomolecules have shown the potential to improve long-term outcomes of fat grafts through enhanced cell survival and higher volume retention. However, the variability between experimental protocols, as well as the scarcity of clinical studies, remain obstacles to clinical translation. In order to determine the best preconditioning method for fat grafts, future studies should focus on dosage optimization, more sustained delivery of the molecules, and the design of homogenous experimental protocols and specific clinical trials.https://www.mdpi.com/2218-273X/15/4/526fat graftingadipose tissuefat graft survivalpreconditioningvolume retentionoxidative stress |
| spellingShingle | Nabil Amraoui Isabelle Xu Jorge Robles Cortés Chanel Beaudoin Cloutier Julie Fradette Improving Fat Graft Survival Using Soluble Molecule Preconditioning Biomolecules fat grafting adipose tissue fat graft survival preconditioning volume retention oxidative stress |
| title | Improving Fat Graft Survival Using Soluble Molecule Preconditioning |
| title_full | Improving Fat Graft Survival Using Soluble Molecule Preconditioning |
| title_fullStr | Improving Fat Graft Survival Using Soluble Molecule Preconditioning |
| title_full_unstemmed | Improving Fat Graft Survival Using Soluble Molecule Preconditioning |
| title_short | Improving Fat Graft Survival Using Soluble Molecule Preconditioning |
| title_sort | improving fat graft survival using soluble molecule preconditioning |
| topic | fat grafting adipose tissue fat graft survival preconditioning volume retention oxidative stress |
| url | https://www.mdpi.com/2218-273X/15/4/526 |
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