Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses
Background: The climate change impacts health and some climate sensitive infectious diseases are indicators that must be actively monitored. The Emilia-Romagna region (northeastern Italy) has adopted a one-health approach to the surveillance of some vector- diseases (VBDs) that became endemic or re-...
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Elsevier
2025-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224004508 |
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| author | Prof Alessandra Scagliarini Alessandra Mistral De Pascali Martina Brandolini Ludovica Ingletto Arianna Succi Mattia Calzolari Valeria Frassineti Giulia Silvestrini Raffaella Angelini Marco Fabbri Irene Zaghi Giorgio Dirani Silvia Zannoli Massimiliano Guerra Francesca Taddei Laura Dionisi Giulia Gatti Claudia Colosimo Carlo Biagetti Francesco Cristini Paolo Bassi Monica Cricca Vittorio Sambri |
| author_facet | Prof Alessandra Scagliarini Alessandra Mistral De Pascali Martina Brandolini Ludovica Ingletto Arianna Succi Mattia Calzolari Valeria Frassineti Giulia Silvestrini Raffaella Angelini Marco Fabbri Irene Zaghi Giorgio Dirani Silvia Zannoli Massimiliano Guerra Francesca Taddei Laura Dionisi Giulia Gatti Claudia Colosimo Carlo Biagetti Francesco Cristini Paolo Bassi Monica Cricca Vittorio Sambri |
| author_sort | Prof Alessandra Scagliarini |
| collection | DOAJ |
| description | Background: The climate change impacts health and some climate sensitive infectious diseases are indicators that must be actively monitored. The Emilia-Romagna region (northeastern Italy) has adopted a one-health approach to the surveillance of some vector- diseases (VBDs) that became endemic or re-emerged (West Nile and leishmaniasis). Over the last two years, the region witnessed extreme weather events that unveiled the environmental vulnerability of its eastern part (Romagna). In 2023-24, massive floodings affected a territory being characterized by national parks, wetlands and semi-extensive agriculture and animal productions, with major consequences on the health and welfare of people and animals. Several research and diagnostic centers are active in the field of human, animal and environmental health making it an ideal context to operationalize one health surveillance. Methods: A multistakeholder network was established to integrate clinical and laboratory diagnosis, vector and animal monitoring, epidemiological and genomic surveillance to allow early detection and characterisation of emerging and re-emerging zoonotic agents. Febrile neurologic surveillance has been put in place to investigate the contribute of ecological and climate trends on these disorders in the Romagna hot spot. The adopted transdisciplinary approach is aimed at designing proper science-based preventive strategies and policies. Results and Discussion: More than 3000 cases of febrile neurologic syndromes were identified over the last 7 years (2017-2023) in Romagna, half of them were classified as Fever of Unknown Origin (FUO), at the time of hospital discharge, with higher incidence during summer months. Major FUO clusters were found in the areas of higher insect abundance, suggesting a possible role of vectorborne infectious agents, not yet included in the official surveillance and diagnostic panels. The integrated One Health genomic surveillance, of West Nile virus (WNV), showed the importance of continuous virus tracking and the value of studying viral genetic diversity to mitigate the impact of this VBD on public health. Moreover, the active WNV surveillance led to identify least-known arboviruses such as Tahyna virus an orthobunyavirus causing undifferentiated fever and influenza-like symptoms, with or without central nervous system involvement that may play a role in some of the identified FUOs. The integrated Leishmania surveillance allowed the identification of several phlebovirus species including neurotropic Toscana virus and other sandfly-transmitted viruses that have not yet been associated with animal and human diseases. Conclusions: For its peculiar geo-ecological characteristics and its vulnerability to extreme climatic events, Romagna is particularly prone to climate sensitive vector and waterborne zoonoses. This ecological, productive, social, and scientific context makes it an ideal living laboratory in which to implement a one-health approach to bridge gaps in surveillance, deepen the epidemiology and guide effective public health responses to emerging climate related health threats, finally showing the value of transdisciplinary collaborations and active stakeholders’ engagement. |
| format | Article |
| id | doaj-art-1b682beebb5841499c8379d5bee7edf5 |
| institution | OA Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-1b682beebb5841499c8379d5bee7edf52025-08-20T02:11:00ZengElsevierInternational Journal of Infectious Diseases1201-97122025-03-0115210737510.1016/j.ijid.2024.107375Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonosesProf Alessandra Scagliarini0Alessandra Mistral De Pascali1Martina Brandolini2Ludovica Ingletto3Arianna Succi4Mattia Calzolari5Valeria Frassineti6Giulia Silvestrini7Raffaella Angelini8Marco Fabbri9Irene Zaghi10Giorgio Dirani11Silvia Zannoli12Massimiliano Guerra13Francesca Taddei14Laura Dionisi15Giulia Gatti16Claudia Colosimo17Carlo Biagetti18Francesco Cristini19Paolo Bassi20Monica Cricca21Vittorio Sambri22Dipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, Italia; UO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Reggio Emilia, ItaliaDipartimento di Sanità Pubblica, ASL Romagna, Ravenna, ItaliaDipartimento di Sanità Pubblica, ASL Romagna, Ravenna, ItaliaDipartimento di Sanità Pubblica, ASL Romagna, Ravenna, ItaliaDipartimento di Sanità Pubblica, ASL Romagna, Ravenna, ItaliaUO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, Italia; Unità di Malattie Infettive, Ospedale di Ravenna, Ravenna, ItaliaUO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaUO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaUO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaUO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, ItaliaUnità di Malattie Infettive, Ospedale di Rimini, Rimini, ItaliaUnità di Malattie Infettive, Ospedale di Cesena, Cesena, ItaliaUnità di Malattie Infettive, Ospedale di Ravenna, Ravenna, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, Italia; UO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaDipartimento di Scienze mediche e Chirurgiche Università di Bologna, Bologna, Italia; UO Microbiologia Laboratorio Unico della Romagna, Pieve Sestina, Cesena, ItaliaBackground: The climate change impacts health and some climate sensitive infectious diseases are indicators that must be actively monitored. The Emilia-Romagna region (northeastern Italy) has adopted a one-health approach to the surveillance of some vector- diseases (VBDs) that became endemic or re-emerged (West Nile and leishmaniasis). Over the last two years, the region witnessed extreme weather events that unveiled the environmental vulnerability of its eastern part (Romagna). In 2023-24, massive floodings affected a territory being characterized by national parks, wetlands and semi-extensive agriculture and animal productions, with major consequences on the health and welfare of people and animals. Several research and diagnostic centers are active in the field of human, animal and environmental health making it an ideal context to operationalize one health surveillance. Methods: A multistakeholder network was established to integrate clinical and laboratory diagnosis, vector and animal monitoring, epidemiological and genomic surveillance to allow early detection and characterisation of emerging and re-emerging zoonotic agents. Febrile neurologic surveillance has been put in place to investigate the contribute of ecological and climate trends on these disorders in the Romagna hot spot. The adopted transdisciplinary approach is aimed at designing proper science-based preventive strategies and policies. Results and Discussion: More than 3000 cases of febrile neurologic syndromes were identified over the last 7 years (2017-2023) in Romagna, half of them were classified as Fever of Unknown Origin (FUO), at the time of hospital discharge, with higher incidence during summer months. Major FUO clusters were found in the areas of higher insect abundance, suggesting a possible role of vectorborne infectious agents, not yet included in the official surveillance and diagnostic panels. The integrated One Health genomic surveillance, of West Nile virus (WNV), showed the importance of continuous virus tracking and the value of studying viral genetic diversity to mitigate the impact of this VBD on public health. Moreover, the active WNV surveillance led to identify least-known arboviruses such as Tahyna virus an orthobunyavirus causing undifferentiated fever and influenza-like symptoms, with or without central nervous system involvement that may play a role in some of the identified FUOs. The integrated Leishmania surveillance allowed the identification of several phlebovirus species including neurotropic Toscana virus and other sandfly-transmitted viruses that have not yet been associated with animal and human diseases. Conclusions: For its peculiar geo-ecological characteristics and its vulnerability to extreme climatic events, Romagna is particularly prone to climate sensitive vector and waterborne zoonoses. This ecological, productive, social, and scientific context makes it an ideal living laboratory in which to implement a one-health approach to bridge gaps in surveillance, deepen the epidemiology and guide effective public health responses to emerging climate related health threats, finally showing the value of transdisciplinary collaborations and active stakeholders’ engagement.http://www.sciencedirect.com/science/article/pii/S1201971224004508 |
| spellingShingle | Prof Alessandra Scagliarini Alessandra Mistral De Pascali Martina Brandolini Ludovica Ingletto Arianna Succi Mattia Calzolari Valeria Frassineti Giulia Silvestrini Raffaella Angelini Marco Fabbri Irene Zaghi Giorgio Dirani Silvia Zannoli Massimiliano Guerra Francesca Taddei Laura Dionisi Giulia Gatti Claudia Colosimo Carlo Biagetti Francesco Cristini Paolo Bassi Monica Cricca Vittorio Sambri Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses International Journal of Infectious Diseases |
| title | Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses |
| title_full | Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses |
| title_fullStr | Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses |
| title_full_unstemmed | Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses |
| title_short | Living Laboratory to operationalize One Health Surveillance of climate related emerging zoonoses |
| title_sort | living laboratory to operationalize one health surveillance of climate related emerging zoonoses |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224004508 |
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