A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

Abstract The intestinal epithelium is the fastest regenerative tissue in the body, fueled by fast‐cycling stem cells. The number and identity of these dividing and migrating stem cells are maintained by a mosaic pattern at the base of the crypt. How the underlying regulatory scheme manages this dyna...

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Main Authors: Kai‐Yuan Chen, Tara Srinivasan, Kuei‐Ling Tung, Julio M Belmonte, Lihua Wang, Preetish Kadur Lakshminarasimha Murthy, Jiahn Choi, Nikolai Rakhilin, Sarah King, Anastasia Kristine Varanko, Mavee Witherspoon, Nozomi Nishimura, James A Glazier, Steven M Lipkin, Pengcheng Bu, Xiling Shen
Format: Article
Language:English
Published: Springer Nature 2017-04-01
Series:Molecular Systems Biology
Subjects:
gene editing
intestine stem cell
Notch signaling
organoid
positive feedback
Online Access:https://doi.org/10.15252/msb.20167324
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