Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics
Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the eliminatio...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/250716 |
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| author | Jonathan B. Ford Mac T. Wayment Timothy E. Albertson Kelly P. Owen Joshua B. Radke Mark E. Sutter |
| author_facet | Jonathan B. Ford Mac T. Wayment Timothy E. Albertson Kelly P. Owen Joshua B. Radke Mark E. Sutter |
| author_sort | Jonathan B. Ford |
| collection | DOAJ |
| description | Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children. |
| format | Article |
| id | doaj-art-1b65f998fa874cd0a87eb3a750df8467 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-1b65f998fa874cd0a87eb3a750df84672025-02-03T06:14:15ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/250716250716Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol PharmacokineticsJonathan B. Ford0Mac T. Wayment1Timothy E. Albertson2Kelly P. Owen3Joshua B. Radke4Mark E. Sutter5Department of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, USADepartment of Pediatrics, School of Medicine, University of California, Davis, 2516 Stockton Boulevard, Suite 221, Sacramento, CA 95817, USADepartment of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, USADepartment of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, USADepartment of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, USADepartment of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, USAPrimary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American male who had a serum ethanol level of 270 mg/dL on admission. A previously healthy 5-week-old African-American male was brought to the ED with a decreased level of consciousness. His initial blood ethanol level was 270 mg/dL. Serial blood ethanol levels were obtained. The elimination rate of ethanol was calculated to be in a range from 17.1 to 21.2 mg/dL/hr and appeared to follow zero-order elimination kinetics with a R2=0.9787. Elimination kinetics for ethanol in the young infant has been reported in only four previously published reports. After reviewing these reports, there appears to be variability in the elimination rates of ethanol in infants. Very young infants may not eliminate ethanol as quickly as previously described. Given that there are different stages of enzyme development in children, caution should be used when generalizing the elimination kinetics in young infants and children.http://dx.doi.org/10.1155/2013/250716 |
| spellingShingle | Jonathan B. Ford Mac T. Wayment Timothy E. Albertson Kelly P. Owen Joshua B. Radke Mark E. Sutter Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics Case Reports in Medicine |
| title | Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics |
| title_full | Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics |
| title_fullStr | Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics |
| title_full_unstemmed | Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics |
| title_short | Elimination Kinetics of Ethanol in a 5-Week-Old Infant and a Literature Review of Infant Ethanol Pharmacokinetics |
| title_sort | elimination kinetics of ethanol in a 5 week old infant and a literature review of infant ethanol pharmacokinetics |
| url | http://dx.doi.org/10.1155/2013/250716 |
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