Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan
Background: Respiratory viral infections significantly burden pediatric populations. These infections are especially concerning in hospitalized children. Co-infection with bacteria may contribute to severe disease in children with respiratory viral infections. Methods: The trend of children's r...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025006097 |
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| author | Chyi-Liang Chen Yi-Ching Chen Hsuan-Ling Hsiao Yi-Jung Chang Hsin-Chieh Li Merve Arslan Aydin Cheng-Hsun Chiu |
| author_facet | Chyi-Liang Chen Yi-Ching Chen Hsuan-Ling Hsiao Yi-Jung Chang Hsin-Chieh Li Merve Arslan Aydin Cheng-Hsun Chiu |
| author_sort | Chyi-Liang Chen |
| collection | DOAJ |
| description | Background: Respiratory viral infections significantly burden pediatric populations. These infections are especially concerning in hospitalized children. Co-infection with bacteria may contribute to severe disease in children with respiratory viral infections. Methods: The trend of children's respiratory infections during and after the pandemic was analyzed. FilmArray RP was used for etiology surveys of hospitalized children with acute respiratory illness in a medical center in northern Taiwan from October 2022 to March 2023. Antimicrobial days of therapy (DOT) were used to measure and compare the antimicrobial consumption between FilmArray RP test-positive and -negative groups. We also reviewed Taiwan CDC's surveillance data in the study period. Results: Among 418 children tested, 271 cases showed positive results; 48.8 % (204/418) had a single virus identified. Multiple viruses were co-circulating in the community starting in September 2022. An increase in the number of influenza cases with severe complications in Taiwan was observed after October 2022. Following these viral infections, cases of invasive pneumococcal disease (IPD) began to increase from September 2022 onward. The FilmArray RP test results did not influence physicians' antibiotic prescribing, as there was no difference in DOT between the test-positive (single, double, or triple viruses-positive) and test-negative groups. However, the average DOTs in both groups were less than 10. Conclusions: Multiple viruses were co-circulating in the community after the pandemic likely due to immune debt. Pediatric physicians continued to use antibiotics for febrile symptoms in hospitalized children with respiratory illness, even when viral pathogens were identified. |
| format | Article |
| id | doaj-art-1b61c1b8f5af4dcf824aeb5cdaa18e99 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-1b61c1b8f5af4dcf824aeb5cdaa18e992025-02-07T04:47:55ZengElsevierHeliyon2405-84402025-02-01113e42229Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, TaiwanChyi-Liang Chen0Yi-Ching Chen1Hsuan-Ling Hsiao2Yi-Jung Chang3Hsin-Chieh Li4Merve Arslan Aydin5Cheng-Hsun Chiu6Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Microbiology and Immunology, College of Medicine, School of Medicine, Chang Gung University, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Pharmacy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, TaiwanMolecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Corresponding author. Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.Background: Respiratory viral infections significantly burden pediatric populations. These infections are especially concerning in hospitalized children. Co-infection with bacteria may contribute to severe disease in children with respiratory viral infections. Methods: The trend of children's respiratory infections during and after the pandemic was analyzed. FilmArray RP was used for etiology surveys of hospitalized children with acute respiratory illness in a medical center in northern Taiwan from October 2022 to March 2023. Antimicrobial days of therapy (DOT) were used to measure and compare the antimicrobial consumption between FilmArray RP test-positive and -negative groups. We also reviewed Taiwan CDC's surveillance data in the study period. Results: Among 418 children tested, 271 cases showed positive results; 48.8 % (204/418) had a single virus identified. Multiple viruses were co-circulating in the community starting in September 2022. An increase in the number of influenza cases with severe complications in Taiwan was observed after October 2022. Following these viral infections, cases of invasive pneumococcal disease (IPD) began to increase from September 2022 onward. The FilmArray RP test results did not influence physicians' antibiotic prescribing, as there was no difference in DOT between the test-positive (single, double, or triple viruses-positive) and test-negative groups. However, the average DOTs in both groups were less than 10. Conclusions: Multiple viruses were co-circulating in the community after the pandemic likely due to immune debt. Pediatric physicians continued to use antibiotics for febrile symptoms in hospitalized children with respiratory illness, even when viral pathogens were identified.http://www.sciencedirect.com/science/article/pii/S2405844025006097ChildrenRespiratory illnessFilmArray RPInvasive pneumococcal diseaseViral-bacterial co-infectionAntimicrobial use |
| spellingShingle | Chyi-Liang Chen Yi-Ching Chen Hsuan-Ling Hsiao Yi-Jung Chang Hsin-Chieh Li Merve Arslan Aydin Cheng-Hsun Chiu Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan Heliyon Children Respiratory illness FilmArray RP Invasive pneumococcal disease Viral-bacterial co-infection Antimicrobial use |
| title | Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan |
| title_full | Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan |
| title_fullStr | Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan |
| title_full_unstemmed | Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan |
| title_short | Multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post-pandemic era, Taiwan |
| title_sort | multiple viral infections and antimicrobial use in hospitalized children with respiratory illness during pandemic and early post pandemic era taiwan |
| topic | Children Respiratory illness FilmArray RP Invasive pneumococcal disease Viral-bacterial co-infection Antimicrobial use |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025006097 |
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