CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages
Circular RNA (circRNA) is a prominent group of non-coding RNA (ncRNA) that regulates gene expression at the post-transcriptional level in various diseases including acute respiratory distress syndrome (ARDS). In our study, circVAMP3 was a novel circRNA significantly increased in macrophages in an ac...
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| Format: | Article |
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PeerJ Inc.
2025-06-01
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| author | Zheng Zhou Shuyang Chen Yajun Wang Shujing Chen Jinjun Jiang |
| author_facet | Zheng Zhou Shuyang Chen Yajun Wang Shujing Chen Jinjun Jiang |
| author_sort | Zheng Zhou |
| collection | DOAJ |
| description | Circular RNA (circRNA) is a prominent group of non-coding RNA (ncRNA) that regulates gene expression at the post-transcriptional level in various diseases including acute respiratory distress syndrome (ARDS). In our study, circVAMP3 was a novel circRNA significantly increased in macrophages in an acute lung injury (ALI) model. Through knockdown and overexpression of circVAMP3, we found circVAMP3 promoted the expression of IFN-β in macrophages, which was vital in the pathophysiological process of ARDS. Moreover, we showed that circVAMP3 targeted Stimulator of Interferon Genes (STING) through miR-580-3p by bioinformatics analysis and intervene of miR-580-3p. CircVAMP3 acts as a pro-inflammation ncRNA by regulating the miR-580-3p/STING/IFN-β axis and could be a potential biomarker and therapeutic target for ARDS. |
| format | Article |
| id | doaj-art-1b57fecd579241b1a2bec7fe430d4ff3 |
| institution | Kabale University |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PeerJ Inc. |
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| series | PeerJ |
| spelling | doaj-art-1b57fecd579241b1a2bec7fe430d4ff32025-08-20T03:24:22ZengPeerJ Inc.PeerJ2167-83592025-06-0113e1957310.7717/peerj.19573CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophagesZheng Zhou0Shuyang Chen1Yajun Wang2Shujing Chen3Jinjun Jiang4Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, ChinaCircular RNA (circRNA) is a prominent group of non-coding RNA (ncRNA) that regulates gene expression at the post-transcriptional level in various diseases including acute respiratory distress syndrome (ARDS). In our study, circVAMP3 was a novel circRNA significantly increased in macrophages in an acute lung injury (ALI) model. Through knockdown and overexpression of circVAMP3, we found circVAMP3 promoted the expression of IFN-β in macrophages, which was vital in the pathophysiological process of ARDS. Moreover, we showed that circVAMP3 targeted Stimulator of Interferon Genes (STING) through miR-580-3p by bioinformatics analysis and intervene of miR-580-3p. CircVAMP3 acts as a pro-inflammation ncRNA by regulating the miR-580-3p/STING/IFN-β axis and could be a potential biomarker and therapeutic target for ARDS.https://peerj.com/articles/19573.pdfCircVAMP3MacrophagesLipopolysaccharideAcute respiratory distress syndromeInterferon-β |
| spellingShingle | Zheng Zhou Shuyang Chen Yajun Wang Shujing Chen Jinjun Jiang CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages PeerJ CircVAMP3 Macrophages Lipopolysaccharide Acute respiratory distress syndrome Interferon-β |
| title | CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages |
| title_full | CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages |
| title_fullStr | CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages |
| title_full_unstemmed | CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages |
| title_short | CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-β axis in macrophages |
| title_sort | circvamp3 promotes acute lung injury progression by regulating the mir 580 3p sting ifn β axis in macrophages |
| topic | CircVAMP3 Macrophages Lipopolysaccharide Acute respiratory distress syndrome Interferon-β |
| url | https://peerj.com/articles/19573.pdf |
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