The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer
ABSTRACT Introduction The purpose of this study was to evaluate the association between body composition, overall survival, odds of receiving treatment, and patient‐reported outcomes (PROs) in individuals living with metastatic non‐small‐cell lung cancer (mNSCLC). Methods This retrospective analysis...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.70534 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543391356125184 |
|---|---|
| author | Adriana M. Coletta Hyejung Lee Sonam Puri Sinead Culleton Matthew F. Covington Jeffrey T. Yap Kelsey E. Maslana Benjamin Haaland Wallace Akerley |
| author_facet | Adriana M. Coletta Hyejung Lee Sonam Puri Sinead Culleton Matthew F. Covington Jeffrey T. Yap Kelsey E. Maslana Benjamin Haaland Wallace Akerley |
| author_sort | Adriana M. Coletta |
| collection | DOAJ |
| description | ABSTRACT Introduction The purpose of this study was to evaluate the association between body composition, overall survival, odds of receiving treatment, and patient‐reported outcomes (PROs) in individuals living with metastatic non‐small‐cell lung cancer (mNSCLC). Methods This retrospective analysis was conducted in newly diagnosed patients with mNSCLC who had computed‐tomography (CT) scans and completed PRO questionnaires close to metastatic diagnosis date. Cox proportional hazard models and logistic regression evaluated overall survival and odds of receiving treatment, respectively. Hazard ratios (HR) and odds ratios (OR) were evaluated as the interquartile range for body composition compartments. Multiple linear regression evaluated the association between PROs and body composition. Models were adjusted for gender, age at diagnosis, smoking history, and mutation status. The survival model also included adjustment for tumor histology. Results Our sample (n = 69) included men (52%) and women (48%), with a median age of 67.4‐years, history of smoking (67%), wild‐type genotype (75.4%), and a tumor histology of adenocarcinoma (68%). Greater skeletal muscle area was associated with higher physical function scores. Larger intermuscular adipose tissue area was associated with higher mortality risk (HR 2.03, 95% CI 1.32, 3.11), lower odds of receiving treatment (OR 0.76, 95% CI 0.61, 0.93), and higher fatigue. Larger subcutaneous adipose tissue area was associated with lower mortality risk (HR 0.42, 95% CI 0.22, 0.82) and higher odds of receiving treatment (OR 1.03, 95% CI 1.01, 1.06). Larger total adipose tissue area was linked with improved survival (HR 0.59, 95% CI 0.36, 0.96). Conclusion Findings support an association between different body composition compartments at mNSCLC diagnosis and survival, decisions to treat, and PROs. This work supports the use of data collected in routine CT scans and PROs to inform treatment decisions and supportive care options. |
| format | Article |
| id | doaj-art-1b4d67fb23e947568dbb4986eb649381 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-1b4d67fb23e947568dbb4986eb6493812025-01-13T13:22:39ZengWileyCancer Medicine2045-76342025-01-01141n/an/a10.1002/cam4.70534The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung CancerAdriana M. Coletta0Hyejung Lee1Sonam Puri2Sinead Culleton3Matthew F. Covington4Jeffrey T. Yap5Kelsey E. Maslana6Benjamin Haaland7Wallace Akerley8Department of Health and Kinesiology The University of Utah Salt Lake City Utah USADivision of Biostatistics, Department of Population Health Sciences The University of Utah Salt Lake City Utah USAThe Huntsman Cancer Institute at the University of Utah Salt Lake City Utah USADepartment of Radiology and Imaging Sciences The University of Utah Salt Lake City Utah USAThe Huntsman Cancer Institute at the University of Utah Salt Lake City Utah USAThe Huntsman Cancer Institute at the University of Utah Salt Lake City Utah USADepartment of Health and Kinesiology The University of Utah Salt Lake City Utah USAThe Huntsman Cancer Institute at the University of Utah Salt Lake City Utah USAThe Huntsman Cancer Institute at the University of Utah Salt Lake City Utah USAABSTRACT Introduction The purpose of this study was to evaluate the association between body composition, overall survival, odds of receiving treatment, and patient‐reported outcomes (PROs) in individuals living with metastatic non‐small‐cell lung cancer (mNSCLC). Methods This retrospective analysis was conducted in newly diagnosed patients with mNSCLC who had computed‐tomography (CT) scans and completed PRO questionnaires close to metastatic diagnosis date. Cox proportional hazard models and logistic regression evaluated overall survival and odds of receiving treatment, respectively. Hazard ratios (HR) and odds ratios (OR) were evaluated as the interquartile range for body composition compartments. Multiple linear regression evaluated the association between PROs and body composition. Models were adjusted for gender, age at diagnosis, smoking history, and mutation status. The survival model also included adjustment for tumor histology. Results Our sample (n = 69) included men (52%) and women (48%), with a median age of 67.4‐years, history of smoking (67%), wild‐type genotype (75.4%), and a tumor histology of adenocarcinoma (68%). Greater skeletal muscle area was associated with higher physical function scores. Larger intermuscular adipose tissue area was associated with higher mortality risk (HR 2.03, 95% CI 1.32, 3.11), lower odds of receiving treatment (OR 0.76, 95% CI 0.61, 0.93), and higher fatigue. Larger subcutaneous adipose tissue area was associated with lower mortality risk (HR 0.42, 95% CI 0.22, 0.82) and higher odds of receiving treatment (OR 1.03, 95% CI 1.01, 1.06). Larger total adipose tissue area was linked with improved survival (HR 0.59, 95% CI 0.36, 0.96). Conclusion Findings support an association between different body composition compartments at mNSCLC diagnosis and survival, decisions to treat, and PROs. This work supports the use of data collected in routine CT scans and PROs to inform treatment decisions and supportive care options.https://doi.org/10.1002/cam4.70534body compositioncancer survivaltreatment decisions |
| spellingShingle | Adriana M. Coletta Hyejung Lee Sonam Puri Sinead Culleton Matthew F. Covington Jeffrey T. Yap Kelsey E. Maslana Benjamin Haaland Wallace Akerley The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer Cancer Medicine body composition cancer survival treatment decisions |
| title | The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer |
| title_full | The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer |
| title_fullStr | The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer |
| title_full_unstemmed | The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer |
| title_short | The Association Between Body Composition, Overall Survival, Treatment Decisions, and Patient‐Reported Outcomes in Metastatic Non‐Small‐Cell Lung Cancer |
| title_sort | association between body composition overall survival treatment decisions and patient reported outcomes in metastatic non small cell lung cancer |
| topic | body composition cancer survival treatment decisions |
| url | https://doi.org/10.1002/cam4.70534 |
| work_keys_str_mv | AT adrianamcoletta theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT hyejunglee theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT sonampuri theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT sineadculleton theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT matthewfcovington theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT jeffreytyap theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT kelseyemaslana theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT benjaminhaaland theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT wallaceakerley theassociationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT adrianamcoletta associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT hyejunglee associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT sonampuri associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT sineadculleton associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT matthewfcovington associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT jeffreytyap associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT kelseyemaslana associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT benjaminhaaland associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer AT wallaceakerley associationbetweenbodycompositionoverallsurvivaltreatmentdecisionsandpatientreportedoutcomesinmetastaticnonsmallcelllungcancer |