Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study
Abstract Parkinson’s disease (PD) reports high rates of morbidity and mortality, but the risk of adverse cardiovascular outcomes in patients with PD has not been fully elucidated. This bi-center retrospective cohort study using the electronic health records (EHR) database of two tertiary hospitals s...
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Nature Portfolio
2024-09-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-72549-y |
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| author | Subin Lim Yun Jin Yum Jong-Ho Kim Chan-Nyoung Lee Hyung Joon Joo Do-Young Kwon |
| author_facet | Subin Lim Yun Jin Yum Jong-Ho Kim Chan-Nyoung Lee Hyung Joon Joo Do-Young Kwon |
| author_sort | Subin Lim |
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| description | Abstract Parkinson’s disease (PD) reports high rates of morbidity and mortality, but the risk of adverse cardiovascular outcomes in patients with PD has not been fully elucidated. This bi-center retrospective cohort study using the electronic health records (EHR) database of two tertiary hospitals screened a total of 327,292 subjects who visited the outpatient clinic, and 1194 patients with PD were propensity score-matched with a control population. The primary outcome was the occurrence of major adverse cardiovascular events (MACE). Key secondary outcomes included all-cause death, cardiovascular (CV) death, stroke, myocardial infarction (MI), heart failure hospitalization and 30-day CV death. After PS matching, MACE occurrence was not significantly different between PD and non-PD groups (18.2% vs. 17.5%, log-rank p = 0.98). Key secondary outcomes were also similar between the two groups. In patients with PD, MACE rate, and also CV risk score, were higher in patients with more severe PD (according to Hoehn and Yahr scale and unified Parkinson’s disease rating scale), and after multivariable analysis, PD severity was not an independent predictor of MACE. Patients with PD are at an increased risk of adverse cardiovascular outcomes, but the contribution from other common CV risk factors cannot be ignored. The management of prevalent CV risk factors is therefore important in mitigating adverse outcomes among patients with PD. |
| format | Article |
| id | doaj-art-1b4c235191a34e8fbf270be10a00fa60 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-1b4c235191a34e8fbf270be10a00fa602025-08-20T02:18:28ZengNature PortfolioScientific Reports2045-23222024-09-0114111110.1038/s41598-024-72549-yCardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort studySubin Lim0Yun Jin Yum1Jong-Ho Kim2Chan-Nyoung Lee3Hyung Joon Joo4Do-Young Kwon5Division of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDepartment of Biostatistics, Korea University College of MedicineKorea University Research Institute for Medical Bigdata Science, Korea University College of MedicineDepartment of Neurology, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDepartment of Neurology, Korea University Ansan HospitalAbstract Parkinson’s disease (PD) reports high rates of morbidity and mortality, but the risk of adverse cardiovascular outcomes in patients with PD has not been fully elucidated. This bi-center retrospective cohort study using the electronic health records (EHR) database of two tertiary hospitals screened a total of 327,292 subjects who visited the outpatient clinic, and 1194 patients with PD were propensity score-matched with a control population. The primary outcome was the occurrence of major adverse cardiovascular events (MACE). Key secondary outcomes included all-cause death, cardiovascular (CV) death, stroke, myocardial infarction (MI), heart failure hospitalization and 30-day CV death. After PS matching, MACE occurrence was not significantly different between PD and non-PD groups (18.2% vs. 17.5%, log-rank p = 0.98). Key secondary outcomes were also similar between the two groups. In patients with PD, MACE rate, and also CV risk score, were higher in patients with more severe PD (according to Hoehn and Yahr scale and unified Parkinson’s disease rating scale), and after multivariable analysis, PD severity was not an independent predictor of MACE. Patients with PD are at an increased risk of adverse cardiovascular outcomes, but the contribution from other common CV risk factors cannot be ignored. The management of prevalent CV risk factors is therefore important in mitigating adverse outcomes among patients with PD.https://doi.org/10.1038/s41598-024-72549-yParkinson’s diseaseCardiovascular diseasesRisk factorsPrognosisPropensity score |
| spellingShingle | Subin Lim Yun Jin Yum Jong-Ho Kim Chan-Nyoung Lee Hyung Joon Joo Do-Young Kwon Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study Scientific Reports Parkinson’s disease Cardiovascular diseases Risk factors Prognosis Propensity score |
| title | Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study |
| title_full | Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study |
| title_fullStr | Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study |
| title_full_unstemmed | Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study |
| title_short | Cardiovascular outcomes in Parkinson’s disease patients from a retrospective cohort study |
| title_sort | cardiovascular outcomes in parkinson s disease patients from a retrospective cohort study |
| topic | Parkinson’s disease Cardiovascular diseases Risk factors Prognosis Propensity score |
| url | https://doi.org/10.1038/s41598-024-72549-y |
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