NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)
Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stabil...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-02-01
|
| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/643 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849243878024019968 |
|---|---|
| author | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov |
| author_facet | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov |
| author_sort | A. V. Shatalova |
| collection | DOAJ |
| description | Introduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stability, etc. Nanobodies can be easily manufactured in microorganisms (E. coli) to significantly save on cost.Text. Goal of the paper consists of the description of structural and functional properties of nanobodies and its effective application.Conclusion. Nanobodies can be used in many fields of medicine and biotechnology such as research, diagnostics and therapy of oncology, infectious, hematological, inflammatory, autoimmune and neurological diseases. They can also be easily modified using another nanobody, molecules or radioactive mark as necessary. Nanobodies have huge potential for applications in diagnostics, therapy and medicine. |
| format | Article |
| id | doaj-art-1b48fd5e5bdb4b40be92c3e827b14a76 |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-02-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-1b48fd5e5bdb4b40be92c3e827b14a762025-08-20T03:59:20ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-02-0181142210.33380/2305-2066-2019-8-1-14-22643NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW)A. V. Shatalova0A. S. Yakubova1V. V. Palimpsestov2I. B. Esmagambetov3Peoples’ Friendship University of Russia (RUDN University)Peoples’ Friendship University of Russia (RUDN University)Moscow Pedagogical State UniversityFederal Research Centre for Epidemiology and Microbiology named after the honorary academician N. F. Gamaleya of the Ministry of Health of the Russian FederationIntroduction. Single-domain antibodies (nanobodies) are composed of the heavy-chain variable domain only. Compared to conventional immunoglobulins G (IgG) nanobodies have such qualities as: high bioavailability, ability to bind epitopes that are difficult to reach, high solubility and thermal stability, etc. Nanobodies can be easily manufactured in microorganisms (E. coli) to significantly save on cost.Text. Goal of the paper consists of the description of structural and functional properties of nanobodies and its effective application.Conclusion. Nanobodies can be used in many fields of medicine and biotechnology such as research, diagnostics and therapy of oncology, infectious, hematological, inflammatory, autoimmune and neurological diseases. They can also be easily modified using another nanobody, molecules or radioactive mark as necessary. Nanobodies have huge potential for applications in diagnostics, therapy and medicine.https://www.pharmjournal.ru/jour/article/view/643nanobodiessingle domain antibodiesvhh |
| spellingShingle | A. V. Shatalova A. S. Yakubova V. V. Palimpsestov I. B. Esmagambetov NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) Разработка и регистрация лекарственных средств nanobodies single domain antibodies vhh |
| title | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_full | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_fullStr | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_full_unstemmed | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_short | NANOBODIES: STRUCTURE, MANUFACTURING, APPLICATION (REVIEW) |
| title_sort | nanobodies structure manufacturing application review |
| topic | nanobodies single domain antibodies vhh |
| url | https://www.pharmjournal.ru/jour/article/view/643 |
| work_keys_str_mv | AT avshatalova nanobodiesstructuremanufacturingapplicationreview AT asyakubova nanobodiesstructuremanufacturingapplicationreview AT vvpalimpsestov nanobodiesstructuremanufacturingapplicationreview AT ibesmagambetov nanobodiesstructuremanufacturingapplicationreview |