State-specific GluCEST alterations in insular subregions are associated with depression and plasma inflammatory biomarker levels in patients with inflammatory bowel disease

Background: Depression commonly co-occurs with inflammatory bowel disease (IBD). Abnormal glutamate levels in the insula and altered plasma inflammatory biomarkers are observed in IBD and depression. However, the changes in glutamate concentrations in insular subregions in IBD and their relationship...

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Main Authors:	Lixue Xu, Jun Lu, Minsi Zhou, Haiyun Shi, Jing Zheng, Tianxin Cheng, Hui Xu, Dawei Yang, Xingwang Yong, Fang Xu, Chenyue Xu, Yan Dang, Zhan Wang, Siying Zhu, Chunsaier Wang, Peng Li, Zhenchang Wang, Jing Wu, Yi Zhang, Zhenghan Yang
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Series:	NeuroImage: Clinical
Subjects:	Brain-immune-gut axis Glutamate chemical exchange saturated transfer Depression Plasma inflammatory biomarker Inflammatory bowel disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213158224001542
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State-specific GluCEST alterations in insular subregions are associated with depression and plasma inflammatory biomarker levels in patients with inflammatory bowel disease

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