Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population

Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood...

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Main Authors: Jun Zhang, Zhiwei Zhang, Yulei Ding, Peng Xu, Tingting Wang, Wenjing Xu, Huan Lu, Jun Li, Yan Wang, Siyuan Li, Zongzhi Liu, Na An, Li Yang, Jianxin Xie
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2015/905042
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author Jun Zhang
Zhiwei Zhang
Yulei Ding
Peng Xu
Tingting Wang
Wenjing Xu
Huan Lu
Jun Li
Yan Wang
Siyuan Li
Zongzhi Liu
Na An
Li Yang
Jianxin Xie
author_facet Jun Zhang
Zhiwei Zhang
Yulei Ding
Peng Xu
Tingting Wang
Wenjing Xu
Huan Lu
Jun Li
Yan Wang
Siyuan Li
Zongzhi Liu
Na An
Li Yang
Jianxin Xie
author_sort Jun Zhang
collection DOAJ
description Our results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P<0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P<0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.
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publisher Wiley
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series Journal of Diabetes Research
spelling doaj-art-1b4209cd79ce48c2a3f1a0a6df8a35362025-08-20T03:54:24ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/905042905042Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs PopulationJun Zhang0Zhiwei Zhang1Yulei Ding2Peng Xu3Tingting Wang4Wenjing Xu5Huan Lu6Jun Li7Yan Wang8Siyuan Li9Zongzhi Liu10Na An11Li Yang12Jianxin Xie13School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832002, ChinaEndocrinology Department of Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi, Xinjiang 830001, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaDepartment of Endocrinology, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaSchool of Medicine, Shihezi University, Shihezi, Xinjiang 832000, ChinaOur results showed that, at the same BMI level, Uygurs have greater WHR values, abdominal visceral fat content, and diabetes risks than Kazaks. In addition, values of HDL-C in Uygur subjects were lower than those in Kazak subjects, and values of creatinine, uric acid, diastolic blood pressure, blood glucose, and fructosamine in Uygur male subjects were lower than those in Kazak male subjects. In contrast, systolic blood pressure values in Uygur subjects were greater than those in Kazak subjects, and blood glucose values were greater in Uygur female subjects than in Kazak female subjects. Additionally, in Uygurs, visceral adipose tissue expression levels of TBX1 and TCF21 were greater in obesity group than in normal and T2DM groups and lower in T2DM group than in normal group (P<0.01). The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P<0.01). In conclusion, T2DM in Uygurs was mainly associated with not only distribution of adipose tissue in body, but also change in metabolic activity and adipocytokines secretion of adipose tissue.http://dx.doi.org/10.1155/2015/905042
spellingShingle Jun Zhang
Zhiwei Zhang
Yulei Ding
Peng Xu
Tingting Wang
Wenjing Xu
Huan Lu
Jun Li
Yan Wang
Siyuan Li
Zongzhi Liu
Na An
Li Yang
Jianxin Xie
Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
Journal of Diabetes Research
title Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
title_full Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
title_fullStr Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
title_full_unstemmed Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
title_short Adipose Tissues Characteristics of Normal, Obesity, and Type 2 Diabetes in Uygurs Population
title_sort adipose tissues characteristics of normal obesity and type 2 diabetes in uygurs population
url http://dx.doi.org/10.1155/2015/905042
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