Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study
Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD)...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/6012795 |
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| author | Rosalinda Posadas-Sánchez Nonanzit Pérez-Hernández Javier Angeles-Martínez Fabiola López-Bautista Teresa Villarreal-Molina José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero Gilberto Vargas-Alarcón |
| author_facet | Rosalinda Posadas-Sánchez Nonanzit Pérez-Hernández Javier Angeles-Martínez Fabiola López-Bautista Teresa Villarreal-Molina José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero Gilberto Vargas-Alarcón |
| author_sort | Rosalinda Posadas-Sánchez |
| collection | DOAJ |
| description | Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, Padd = 0.036; OR = 0.614, Prec = 0.033; OR = 0.591, Pcod2 = 0.027) and IL-12A rs2243115 (OR = 0.674, Padd = 0.010; OR = 0.676, Pdom = 0.014; OR = 0.698, Phet = 0.027; OR = 0.694, Pcod1 = 0.024) polymorphisms were associated with decreased risk of developing premature CAD. Some polymorphisms were associated with clinical and metabolic parameters. Significant different levels of IL-35 were observed in EBI3 rs4740 and rs4905 genotypes only in the group of healthy controls. In summary, our study suggests that the EBI3 and IL-12A polymorphisms play an important role in decreasing the risk of developing premature CAD; it also demonstrates the relationship of the EBI3 rs4740 and rs4905 genotypes with IL-35 levels in healthy individuals. |
| format | Article |
| id | doaj-art-1b3cf45cd00c42faa21f128c869c8029 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1b3cf45cd00c42faa21f128c869c80292025-08-20T02:02:20ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/60127956012795Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) StudyRosalinda Posadas-Sánchez0Nonanzit Pérez-Hernández1Javier Angeles-Martínez2Fabiola López-Bautista3Teresa Villarreal-Molina4José Manuel Rodríguez-Pérez5José Manuel Fragoso6Carlos Posadas-Romero7Gilberto Vargas-Alarcón8Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoCardiovascular Genomics Laboratory, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, MexicoInterleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individuals. The IL-12A and EBI3 polymorphisms were determined in 1162 patients with premature CAD and 873 controls. Under different models, the EBI3 rs428253 (OR = 0.831, Padd = 0.036; OR = 0.614, Prec = 0.033; OR = 0.591, Pcod2 = 0.027) and IL-12A rs2243115 (OR = 0.674, Padd = 0.010; OR = 0.676, Pdom = 0.014; OR = 0.698, Phet = 0.027; OR = 0.694, Pcod1 = 0.024) polymorphisms were associated with decreased risk of developing premature CAD. Some polymorphisms were associated with clinical and metabolic parameters. Significant different levels of IL-35 were observed in EBI3 rs4740 and rs4905 genotypes only in the group of healthy controls. In summary, our study suggests that the EBI3 and IL-12A polymorphisms play an important role in decreasing the risk of developing premature CAD; it also demonstrates the relationship of the EBI3 rs4740 and rs4905 genotypes with IL-35 levels in healthy individuals.http://dx.doi.org/10.1155/2017/6012795 |
| spellingShingle | Rosalinda Posadas-Sánchez Nonanzit Pérez-Hernández Javier Angeles-Martínez Fabiola López-Bautista Teresa Villarreal-Molina José Manuel Rodríguez-Pérez José Manuel Fragoso Carlos Posadas-Romero Gilberto Vargas-Alarcón Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study Mediators of Inflammation |
| title | Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study |
| title_full | Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study |
| title_fullStr | Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study |
| title_full_unstemmed | Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study |
| title_short | Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study |
| title_sort | interleukin 35 polymorphisms are associated with decreased risk of premature coronary artery disease metabolic parameters and il 35 levels the genetics of atherosclerotic disease gea study |
| url | http://dx.doi.org/10.1155/2017/6012795 |
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