Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate
The damaging effects of heavy metal exposure on vital organs like the heart, liver, kidneys, and brain can be lowered by natural compounds' anti-inflammatory and anti-oxidant capacity. In the current investigation, the protective potential of savory(Saturejahortensis)essential oil (EO) against...
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Elsevier
2025-03-01
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| Series: | Biotechnology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X24000444 |
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| author | Doha H. Aboubaker Nermeen A. Shaffie Mona F. Shabana Ahmed Abd Elghafour Bassant M.M. Ibrahim |
| author_facet | Doha H. Aboubaker Nermeen A. Shaffie Mona F. Shabana Ahmed Abd Elghafour Bassant M.M. Ibrahim |
| author_sort | Doha H. Aboubaker |
| collection | DOAJ |
| description | The damaging effects of heavy metal exposure on vital organs like the heart, liver, kidneys, and brain can be lowered by natural compounds' anti-inflammatory and anti-oxidant capacity. In the current investigation, the protective potential of savory(Saturejahortensis)essential oil (EO) against lead acetate-induced multi-organ damage in rats was evaluated. Thirty female Wister Albino rats were divided into the following groups: normal, positive control given lead acetate without concomitant treatment, reference given ethylene-diamine-tetra-acetic acid and groups treated with savory EO (0.5 and 1 ml/rat), treatments were administered concomitantly with lead acetate for ten successive days. Electrocardiogram (ECG), open field, and rota-rod tests for evaluation of behaviour, as well as TNF-α, R-GSH & MDA were measured in brain and liver homogenates respectively, CRP, liver, kidney, and heart function tests, were measured in serum. Histopathology of vital organs was conducted at the end of the experiment.A high dose of savory EO, significantly improved the cardiac electrophysiology, psychological state, and locomotor activity of rats; moreover, it lowered inflammatory, oxidative biomarkers, liver, kidney, and cardiac function tests of the rats. Savory EO protects vital organs against heavy metal damage with the superiority of the high dose. |
| format | Article |
| id | doaj-art-1b384ff82a8b45f79107d0589a436284 |
| institution | OA Journals |
| issn | 2215-017X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj-art-1b384ff82a8b45f79107d0589a4362842025-08-20T02:00:46ZengElsevierBiotechnology Reports2215-017X2025-03-0145e0087110.1016/j.btre.2024.e00871Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetateDoha H. Aboubaker0Nermeen A. Shaffie1Mona F. Shabana2Ahmed Abd Elghafour3Bassant M.M. Ibrahim4Medicinal and Aromatic Plants Department, National Research Centre, Dokki, Giza, Egypt; Corresponding author.Pathology Department, National Research Centre, Giza, EgyptMedical Pharmacology Department, Faculty of Medicine-Fayoum University, Fayoum, EgyptMedicinal and Aromatic Plants Department, National Research Centre, Dokki, Giza, EgyptPharmacology Department, National Research Centre, Dokki, Giza, EgyptThe damaging effects of heavy metal exposure on vital organs like the heart, liver, kidneys, and brain can be lowered by natural compounds' anti-inflammatory and anti-oxidant capacity. In the current investigation, the protective potential of savory(Saturejahortensis)essential oil (EO) against lead acetate-induced multi-organ damage in rats was evaluated. Thirty female Wister Albino rats were divided into the following groups: normal, positive control given lead acetate without concomitant treatment, reference given ethylene-diamine-tetra-acetic acid and groups treated with savory EO (0.5 and 1 ml/rat), treatments were administered concomitantly with lead acetate for ten successive days. Electrocardiogram (ECG), open field, and rota-rod tests for evaluation of behaviour, as well as TNF-α, R-GSH & MDA were measured in brain and liver homogenates respectively, CRP, liver, kidney, and heart function tests, were measured in serum. Histopathology of vital organs was conducted at the end of the experiment.A high dose of savory EO, significantly improved the cardiac electrophysiology, psychological state, and locomotor activity of rats; moreover, it lowered inflammatory, oxidative biomarkers, liver, kidney, and cardiac function tests of the rats. Savory EO protects vital organs against heavy metal damage with the superiority of the high dose.http://www.sciencedirect.com/science/article/pii/S2215017X24000444Satureja hortensisEssential oilProtectiveBrainKidneysLiver |
| spellingShingle | Doha H. Aboubaker Nermeen A. Shaffie Mona F. Shabana Ahmed Abd Elghafour Bassant M.M. Ibrahim Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate Biotechnology Reports Satureja hortensis Essential oil Protective Brain Kidneys Liver |
| title | Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| title_full | Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| title_fullStr | Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| title_full_unstemmed | Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| title_short | Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| title_sort | protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate |
| topic | Satureja hortensis Essential oil Protective Brain Kidneys Liver |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X24000444 |
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