An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip
<b>Introduction:</b> This study explores the bioactive properties of extracts obtained from Robin’s pincushion (<i>Diplolepis rosae</i>) collected in Sokobanja, Serbia. <b>Results:</b> Comprehensive in vitro assessments reveal high concentrations of total phenolic...
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2024-12-01
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| author | Olja Šovljanski Milica Aćimović Teodora Cvanić Vanja Travičić Aleksandra Popović Jelena Vulić Gordana Ćetković Aleksandra Ranitović Ana Tomić |
| author_facet | Olja Šovljanski Milica Aćimović Teodora Cvanić Vanja Travičić Aleksandra Popović Jelena Vulić Gordana Ćetković Aleksandra Ranitović Ana Tomić |
| author_sort | Olja Šovljanski |
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| description | <b>Introduction:</b> This study explores the bioactive properties of extracts obtained from Robin’s pincushion (<i>Diplolepis rosae</i>) collected in Sokobanja, Serbia. <b>Results:</b> Comprehensive in vitro assessments reveal high concentrations of total phenolics (186.37 mg GAE/g), along with significant levels of carotenoids (44.10 μg β-car/g). Robin’s pincushion exhibited superior antioxidant capacities across DPPH, ABTS, and reducing power assays, significantly outperforming comparable extracts from rosehip (<i>Rosa canina</i>) and black rosehip (<i>Rosa spinosissima</i>) in these activities. Additionally, high inhibitory effects were observed in antimicrobial assays, with the extract demonstrating minimal inhibitory concentrations (MIC) as low as 1.56 mg/mL against the <i>Staphylococcus</i> species. Notably, the extract achieved full bactericidal effect within 24 h in time-kill kinetic studies which additionally highlight its potent antistaphylococcal potential. <b>Materials and methods:</b> Analyzing their phytochemical profiles and evaluating their potential as antioxidant, anti-inflammatory, antihyperglycemic, and antimicrobial agents, wide-ranging evaluation of bioactivity of Robin’s pincushion was conducted. <b>Conclusions:</b> These findings highlight Robin’s pincushion as a promising natural source of bioactive compounds with potential applications in traditional and modern medicine for managing oxidative stress, inflammation, hyperglycemia, and microbial infections. |
| format | Article |
| id | doaj-art-1b37d70248f54ea28cb8e191eb3b11b3 |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Antibiotics |
| spelling | doaj-art-1b37d70248f54ea28cb8e191eb3b11b32025-08-20T02:53:18ZengMDPI AGAntibiotics2079-63822024-12-011312117810.3390/antibiotics13121178An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black RosehipOlja Šovljanski0Milica Aćimović1Teodora Cvanić2Vanja Travičić3Aleksandra Popović4Jelena Vulić5Gordana Ćetković6Aleksandra Ranitović7Ana Tomić8Faculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaInstitute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaFaculty of Agriculture Novi Sad, University of Novi Sad, Trg Dositeja Obradovića 8, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, SerbiaFaculty of Technology Novi Sad, University of Novi Sad, Bulevar Cara Lazara 1, 21000 Novi Sad, Serbia<b>Introduction:</b> This study explores the bioactive properties of extracts obtained from Robin’s pincushion (<i>Diplolepis rosae</i>) collected in Sokobanja, Serbia. <b>Results:</b> Comprehensive in vitro assessments reveal high concentrations of total phenolics (186.37 mg GAE/g), along with significant levels of carotenoids (44.10 μg β-car/g). Robin’s pincushion exhibited superior antioxidant capacities across DPPH, ABTS, and reducing power assays, significantly outperforming comparable extracts from rosehip (<i>Rosa canina</i>) and black rosehip (<i>Rosa spinosissima</i>) in these activities. Additionally, high inhibitory effects were observed in antimicrobial assays, with the extract demonstrating minimal inhibitory concentrations (MIC) as low as 1.56 mg/mL against the <i>Staphylococcus</i> species. Notably, the extract achieved full bactericidal effect within 24 h in time-kill kinetic studies which additionally highlight its potent antistaphylococcal potential. <b>Materials and methods:</b> Analyzing their phytochemical profiles and evaluating their potential as antioxidant, anti-inflammatory, antihyperglycemic, and antimicrobial agents, wide-ranging evaluation of bioactivity of Robin’s pincushion was conducted. <b>Conclusions:</b> These findings highlight Robin’s pincushion as a promising natural source of bioactive compounds with potential applications in traditional and modern medicine for managing oxidative stress, inflammation, hyperglycemia, and microbial infections.https://www.mdpi.com/2079-6382/13/12/1178<i>Rosa canina</i><i>Rosa spinosissima</i><i>Diplolepsis rosae</i>rose gall waspantioxidant activityantihyperglycemic |
| spellingShingle | Olja Šovljanski Milica Aćimović Teodora Cvanić Vanja Travičić Aleksandra Popović Jelena Vulić Gordana Ćetković Aleksandra Ranitović Ana Tomić An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip Antibiotics <i>Rosa canina</i> <i>Rosa spinosissima</i> <i>Diplolepsis rosae</i> rose gall wasp antioxidant activity antihyperglycemic |
| title | An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip |
| title_full | An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip |
| title_fullStr | An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip |
| title_full_unstemmed | An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip |
| title_short | An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip |
| title_sort | in vitro evaluation of robin s pincushion extract as a novel bioactive based antistaphylococcal agent comparison to rosehip and black rosehip |
| topic | <i>Rosa canina</i> <i>Rosa spinosissima</i> <i>Diplolepsis rosae</i> rose gall wasp antioxidant activity antihyperglycemic |
| url | https://www.mdpi.com/2079-6382/13/12/1178 |
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