An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip

An In Vitro Evaluation of Robin’s Pincushion Extract as a Novel Bioactive-Based Antistaphylococcal Agent—Comparison to Rosehip and Black Rosehip

<b>Introduction:</b> This study explores the bioactive properties of extracts obtained from Robin’s pincushion (<i>Diplolepis rosae</i>) collected in Sokobanja, Serbia. <b>Results:</b> Comprehensive in vitro assessments reveal high concentrations of total phenolic...

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Main Authors: Olja Šovljanski, Milica Aćimović, Teodora Cvanić, Vanja Travičić, Aleksandra Popović, Jelena Vulić, Gordana Ćetković, Aleksandra Ranitović, Ana Tomić
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
<i>Rosa canina</i>
<i>Rosa spinosissima</i>
<i>Diplolepsis rosae</i>
rose gall wasp
antioxidant activity
antihyperglycemic
Online Access:https://www.mdpi.com/2079-6382/13/12/1178
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Summary:<b>Introduction:</b> This study explores the bioactive properties of extracts obtained from Robin’s pincushion (<i>Diplolepis rosae</i>) collected in Sokobanja, Serbia. <b>Results:</b> Comprehensive in vitro assessments reveal high concentrations of total phenolics (186.37 mg GAE/g), along with significant levels of carotenoids (44.10 μg β-car/g). Robin’s pincushion exhibited superior antioxidant capacities across DPPH, ABTS, and reducing power assays, significantly outperforming comparable extracts from rosehip (<i>Rosa canina</i>) and black rosehip (<i>Rosa spinosissima</i>) in these activities. Additionally, high inhibitory effects were observed in antimicrobial assays, with the extract demonstrating minimal inhibitory concentrations (MIC) as low as 1.56 mg/mL against the <i>Staphylococcus</i> species. Notably, the extract achieved full bactericidal effect within 24 h in time-kill kinetic studies which additionally highlight its potent antistaphylococcal potential. <b>Materials and methods:</b> Analyzing their phytochemical profiles and evaluating their potential as antioxidant, anti-inflammatory, antihyperglycemic, and antimicrobial agents, wide-ranging evaluation of bioactivity of Robin’s pincushion was conducted. <b>Conclusions:</b> These findings highlight Robin’s pincushion as a promising natural source of bioactive compounds with potential applications in traditional and modern medicine for managing oxidative stress, inflammation, hyperglycemia, and microbial infections.
ISSN:2079-6382

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