Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression

Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression

ABSTRACT This study investigates the role of interleukin 6 antisense RNA 1 (IL6‐AS1), a highly expressed long noncoding RNA (lncRNA), in chronic obstructive pulmonary disease (COPD). An adeno‐associated virus (AAV) was used to induce the expression of IL6‐AS1 in mice, and they were exposed to cigare...

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Main Authors: Erkang Yi, Xiaoyu Wang, Yu Liu, Zihui Wang, Ge Bai, Xinyue Mei, Fan Wu, Chengshu Xie, QiYang Li, Weitao Cao, Huahua Xu, Xinyuan Liu, Jieda Cui, Haiqing Li, Ruiting Sun, Xinru Ran, Wei Hong, Zhishan Deng, Bing Li, Yumin Zhou, Pixin Ran
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:MedComm
Subjects:
chronic obstructive pulmonary disease
lncRNA interleukin 6 antisense RNA 1
S100A9
macrophages
Mendelian randomization
Online Access:https://doi.org/10.1002/mco2.70204
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